High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity.
High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity.
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DOI：
10.1055/s-0029-1224174
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发表时间：
2009-09
影响因子：
2.5
通讯作者：
Cortright RN
中科院分区：
文献类型：
--
作者：
Bikman BT;Woodlief TL;Noland RC;Britton SL;Koch LG;Lust RM;Dohm GL;Cortright RN
与那些为低跑步能力（LCR）而饲养的大鼠相比，为高跑步能力（HCR）而饲养的大鼠在高脂肪饮食（HFD）中不会产生胰岛素抵抗。最近，肥胖和胰岛素抵抗之间的联系已经通过IKKβ作用和IRS-1 Ser 312/307磷酸化而建立。本研究测定了HFD 12周激发的HCR和LCR大鼠混合腓肠肌中IκBα和IRS-1 pSer 307。HFD治疗导致LCR大鼠的葡萄糖和胰岛素水平显著高于HCR大鼠。IκBα水平（IKKβ活性的反向指标）在维持普通饲料的LCR大鼠中低于HCR大鼠，并且仅在LCR大鼠中在HFD后进一步降低。LCR大鼠中的IRS-1 pSer 307在HFD上相对于食物增加。我们的结论是，LCR和HCR大鼠之间葡萄糖耐量的差异至少部分地解释了IKKβ活性和pSer 307水平的差异。
Rats bred for a high-capacity to run (HCR) do not develop insulin resistance on a high-fat diet (HFD) vs. those bred for a low-capacity for running (LCR). Recently, a link between obesity and insulin resistance has been established via IKKβ action and IRS-1 Ser312/307 phosphorylation. This study measured IκBα and IRS-1 pSer 307 in mixed gastrocnemius muscle in HCR and LCR rats challenged with a 12-wk HFD. HFD treatment resulted in significantly higher glucose and insulin levels in LCR vs. HCR rats. IκBα levels, an inverse indicator of IKKβ activity, were lower in LCR vs. HCR rats maintained on chow diet and were reduced further following HFD in LCR rats only. IRS-1 pSer307 in the LCR rats increased on the HFD vs. chow. We conclude that differences in glucose tolerance between LCR and HCR rats are at least partly explained by differences in IKKβ activity and pSer307 levels.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
7
作者：
Hulver, MW;Dohm, GL
通讯作者：
Dohm, GL
影响因子：
7.7
作者：
Morino, Katsutaro;Petersen, Kitt Falk;Shulman, Gerald I.
通讯作者：
Shulman, Gerald I.
DOI：
10.1152/ajpendo.00500.2006
发表时间：
2007-07-01
影响因子：
5.1
作者：
Noland, Robert C.;Thyfault, John P.;Lust, Robert M.
通讯作者：
Lust, Robert M.
影响因子：
4.8
作者：
Ji, LL;Gomez-Cabrera, MC;Vina, J
通讯作者：
Vina, J