Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis
Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis
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DOI：
10.1093/rheumatology/40.5.574
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发表时间：
2001-05-01
期刊：
影响因子：
5.5
通讯作者：
Woo, P
中科院分区：
文献类型：
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作者：
Crawley, E;Kon, S;Woo, P
Objective.为了确定是否扩大少关节幼年特发性关节炎（JIA）的儿童产生较少的抗炎细胞因子白细胞介素-10（IL-10）比那些持续少关节JIA。我们检测了少关节炎扩展性少关节型JIA患儿父母在脂多糖刺激下全血培养中IL-10的产生。与少关节型JIA儿童相比，广泛少关节型JIA儿童的父母IL-10产生较低（P = 0.034）。与健康对照组相比，广泛性少关节型JIA患儿的父母中含有ATA基因型（即ATA ATA、ATA ACC或ATA GCC）的比例增加（P
Objective. To determine whether children with extended oligoarticular juvenile idiopathic arthritis (JIA) produce less of the anti-inflammatory cytokine interleukin-10 (IL-10) than those with persistent oligoarticular JIA.Methods. We measured IL-10 production in the parents of children with oligoarticular ol extended oligoarticular JIA, from whole-blood cultures stimulated with lipopolysaccharide.Results. IL-10 production was lower in the parents of children with extended oligoarticular JIA compared with those of children with oligoarticular JIA (P = 0.034). There was an increase in the percentage of ATA-containing genotypes (i.e. genotypes ATA ATA, ATA ACC ol ATA GCC) in the parents of children with extended oligoarticular JIA compared with healthy controls (P