Metabolic syndrome and its relationship with the achievement of minimal disease activity state in psoriatic arthritis patients: an observational study
Metabolic syndrome and its relationship with the achievement of minimal disease activity state in psoriatic arthritis patients: an observational study
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DOI：
10.1007/s12026-014-8595-z
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发表时间：
2015-02-01
影响因子：
4.4
通讯作者：
Scarpa, Raffaele
中科院分区：
文献类型：
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作者：
Costa, Luisa;Caso, Francesco;Scarpa, Raffaele
本研究的目的是评估代谢综合征（MetS）对接受抗肿瘤坏死因子（TNF）-α治疗的银屑病关节炎（PsA）患者达到最小疾病活动度（MDA）的影响，随访期为24个月。在那不勒斯的费德里科二世大学和帕多瓦大学对一组PsA患者进行了评估。为了本研究的目的，在基线（T0）、12个月（T1）和24个月（T2）时收集患者数据。在每次访视时评估代谢和疾病活动参数。NCEP-ACT III标准用于识别MetS受试者，MDA标准用于评估疾病活动性。根据排除和入选标准，330例受试者入选研究; 134例患者（40.7%）被归类为未患MetS，196例（59.3%）被归类为患有MetS。发现代谢综合征的存在与达到MDA的可能性之间呈负相关。单因素分析显示，代谢综合征患者较非代谢综合征患者更不容易达到MDA（OR 0.45，p <0.001）。这种负相关在多变量回归模型中仍然具有统计学显著性（OR 0.56，p <0.001）。抗TNF-α治疗的PsA患者中，代谢综合征与达到MDA的可能性较低相关。
The aim of the study was to evaluate the influence of metabolic syndrome (MetS) on achieving minimal disease activity (MDA) in psoriatic arthritis (PsA) patients treated with anti-tumor necrosis factor (TNF)-alpha with a follow-up period of 24 months. A cohort of PsA patients was assessed at the University Federico II of Naples and at University of Padova. For the aim of the present study, patients' data were collected at baseline (T0), at 12 months (T1) and at 24 months (T2). Assessment of metabolic and disease activity parameters was performed at each visit. The NCEP-ACT III criteria were used to identify subjects with MetS and the MDA criteria to evaluate the disease activity. On the basis of the exclusion and inclusion criteria, 330 subjects were included in the study; 134 patients (40.7 %) were classified as not having MetS and 196 (59.3 %) as having MetS. An inverse association was found between presence of metabolic syndrome and the probability of achieving MDA. Univariate analysis indicated that patients with metabolic syndrome were less likely to achieve MDA than patients without metabolic syndrome (OR 0.45, p < 0.001). This inverse association remained statistically significant in the multivariate regression model (OR 0.56, p < 0.001). Metabolic syndrome is associated with a lower probability of achieving MDA in PsA patients in therapy with anti-TNF-alpha.