Persistent Microbial Translocation and Immune Activation in HIV-1-Infected South Africans Receiving Combination Antiretroviral Therapy
Persistent Microbial Translocation and Immune Activation in HIV-1-Infected South Africans Receiving Combination Antiretroviral Therapy
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DOI：
10.1086/655229
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发表时间：
2010-09-01
影响因子：
6.4
通讯作者：
Rossouw, Theresa
中科院分区：
文献类型：
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作者：
Cassol, Edana;Malfeld, Susan;Rossouw, Theresa
背景。微生物易位有助于慢性人类免疫缺陷病毒 1 型 (HIV-1) 感染期间的免疫激活和疾病进展。然而，它在非洲艾滋病流行中的作用仍然存在争议。在这里，我们研究了优先接受联合抗逆转录病毒治疗 (cART) 的南非人中单核细胞活化标记物、血浆脂多糖 (LPS) 和 HIV-1 RNA 之间的关系。方法。 10 名 HIV-1 阴性非洲对照者和 80 名 HIV-1 感染患者的 CD4 T 细胞计数
Background. Microbial translocation contributes to immune activation and disease progression during chronic human immunodeficiency virus type 1 (HIV-1) infection. However, its role in the African AIDS epidemic remains controversial. Here, we investigated the relationship between markers of monocyte activation, plasma lipopolysaccharide (LPS), and HIV-1 RNA in South Africans prioritized to receive combination antiretroviral therapy (cART).Methods. Ten HIV-1-negative African controls and 80 HIV-1-infected patients with CD4 T cell counts