Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex.
Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex.
复制标题
会内神经元网的耗竭增强了周围皮层的识别记忆和长期抑郁症。
DOI：
10.1523/jneurosci.6267-11.2013
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发表时间：
2013-04-17
期刊：
影响因子：
--
通讯作者：
Saksida LM
中科院分区：
文献类型：
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作者：
Romberg C;Yang S;Melani R;Andrews MR;Horner AE;Spillantini MG;Bussey TJ;Fawcett JW;Pizzorusso T;Saksida LM
神经元周网是围绕皮层神经元细胞体和近端树突的细胞外基质结构，参与大脑可塑性的控制和关键期的关闭。连接蛋白Crtl 1/Hapln 1在神经元中的表达最近被确定为触发神经元周围网络形成的关键事件。在这里，我们表明，在成年大脑Crtl 1基因敲除小鼠的神经元周围网络的遗传衰减增强长期的物体识别记忆和促进长期抑郁症的嗅周皮层，神经相关的物体识别记忆。相同的记忆延长以下局部消化神经束膜网与软骨素酶ABC，一种酶，降解硫酸软骨素蛋白多糖（CSPGs）的PNN组件。软骨素酶ABC治疗的记忆增强作用随着时间的推移而减弱，表明PNN的再生逐渐恢复控制可塑性水平。我们的研究结果表明，神经元周围网络调节记忆和经验驱动的突触可塑性在成年期。
Perineuronal nets are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites, and are involved in the control of brain plasticity and the closure of critical periods. Expression of the link protein Crtl1/Hapln1 in neurons has recently been identified as the key event triggering the formation of perineuronal nets. Here we show that the genetic attenuation of perineuronal nets in adult brain Crtl1 knockout mice enhances long term object recognition memory and facilitates long-term depression in the perirhinal cortex, a neural correlate of object recognition memory. Identical prolongation of memory follows localised digestion of perineuronal nets with chondroitinase ABC, an enzyme that degrades the chondroitin sulphate proteoglycans (CSPGs) components of PNNs. The memory-enhancing effect of chondroitinase ABC treatment attenuated over time, suggesting that regeneration of PNNs gradually restored control plasticity levels. Our findings indicate that perineuronal nets regulate both memory and experience-driven synaptic plasticity in adulthood.