Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the Atherosclerosis Risk in Communities Study).
Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the Atherosclerosis Risk in Communities Study).
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DOI：
10.1016/j.amjcard.2014.07.073
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发表时间：
2014-11-01
影响因子：
2.8
通讯作者：
Herrington, David
中科院分区：
文献类型：
--
作者：
Qureshi, Waqas;Soliman, Elsayed Z.;Solomon, Scott D.;Alonso, Alvaro;Arking, Dan E.;Shah, Amil;Gupta, Deepak K.;Wagenknecht, Lynne E.;Herrington, David
关于正常大小左心房（LA）患者房颤（AF）风险因素的流行病学数据有限。我们评估了正常大小和扩张左心房患者之间传统的房颤风险因素是否不同。这是一项针对社区动脉粥样硬化风险研究的社区居住参与者的横断面研究。用二维超声心动图测量左心房容积指数（LAVI）。LAVI ≥ 29 mm 3/m2定义为扩张的LA。通过心电图和出院国际疾病分类-9代码定义流行性AF。采用多变量校正logistic回归分析，以检查左心房腔大小是否与房颤的危险因素相关程度不同。评估了左心房腔大小与风险因素的相互作用，以确定这些差异相关性的显著性。在5496名参与者（平均年龄75±5岁，女性58%）中，1230名（22%）患有左心房扩张。房颤的患病率在左心房大小正常的个体中为11%，在左心房扩张的个体中为15%。年龄>75岁[比值比（OR）1.87; 95%置信区间（CI）1.49 - 2.35，相互作用p=0.12]和心力衰竭（OR 5.43; 95% CI 3.77 - 7.87，相互作用p=0.10）是正常尺寸LA中AF的更强风险因素。女性性（OR 1.67; 95% CI 1.01 - 2.77，相互作用p=0.09），体重（OR 1.32; 95% CI 1.02 - 1.71，交互作用p=0.19）和饮酒（OR 1.61; 95% CI 1.08 - 2.41，相互作用p=0.004）是左心房扩张个体中AF的更强风险因素。总之，房颤的危险因素可能因左心室腔大小而异。
Epidemiological data are limited regarding risk factors of atrial fibrillation (AF) in patients with normal-sized left atria (LA). We evaluated whether traditional risk factors of AF differ between patients with normal-sized and dilated LA. This is a cross sectional study of community-dwelling participants of Atherosclerosis Risk in Communities Study. LA volume index (LAVI) was measured by 2-dimensional echocardiography. LAVI ≥29mm3/m2 defined dilated LA. Prevalent AF was defined by electrocardiogram and hospital discharge international classification of diseases - 9 codes. Multivariable adjusted logistic regression analysis was used to examine whether magnitude of association of risk factors with AF differ by LA cavity size. Interaction of risk factors by LA cavity size was evaluated to determine significance of these differential associations. Of 5496 participants (mean age 75±5 years, women 58%), 1230 (22%) had dilated LA. The prevalence of AF was 11% in individuals with normal-sized LA and 15% in individuals with dilated LA. Age >75 years [Odds Ratio (OR) 1.87; 95% confidence interval (CI) 1.49 – 2.35, interaction p=0.12] and heart failure (OR 5.43; 95% CI 3.77 – 7.87, interaction p=0.10) were stronger risk factors for AF in normal-sized LA than dilated-LA. Female sex (OR 1.67; 95% CI 1.01 – 2.77, interaction p=0.09), weight (OR 1.32; 95% CI 1.02 – 1.71, interaction p=0.19) and alcohol-use (OR 1.61; 95% CI 1.08 – 2.41, interaction p=0.004) were stronger risk factors for AF in individuals with dilated LA than normal-sized LA. In conclusion, risk factors of AF may differ by left ventricular cavity size.
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影响因子：
37.8
作者：
HENRY, WL;MORGANROTH, J;EPSTEIN, SE
通讯作者：
EPSTEIN, SE
DOI：
10.1067/mje.2001.113258
发表时间：
2001-06-01
影响因子：
6.5
作者：
Ilercil, A;O'Grady, MJ;Devereux, RB
通讯作者：
Devereux, RB
影响因子：
3.1
作者：
GARBER, EB;MORGAN, MG;GLASSER, SP
通讯作者：
GLASSER, SP
影响因子：
7.2
作者：
Sorlie, PD;Cooper, L;Szklo, M
通讯作者：
Szklo, M
影响因子：
3.5
作者：
Cheng, Tsung O.
通讯作者：
Cheng, Tsung O.