Ties in Tourette syndrome: New treatment options
Ties in Tourette syndrome: New treatment options
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DOI：
10.1177/088307389901400508
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发表时间：
1999-05-01
影响因子：
1.9
通讯作者：
Awaad, Y
中科院分区：
文献类型：
--
作者：
Awaad, Y
抽动秽语综合征是一种家族性神经行为障碍，其特征在于波动的不自主运动和/或声音联系。最常用的治疗抽动秽语综合征的药物是氟哌啶醇、匹莫齐特、氟奋乃静和可乐定，所有这些药物都可能有相当大的副作用。我们招募了450例抽动/抽动秽语综合征患者，根据其症状使用巴氯芬/A型肉毒毒素治疗。抽动症状的整体严重程度由耶鲁整体抽动严重程度量表和定量录像带的关系的微结构分析来评定。我们发现巴氯芬/A型肉毒毒素治疗抽动/抽动秽语综合征是非常有效、安全和可靠的。值得在抽动/抽动秽语综合征患者中考虑这种治疗方法，以减少或避免其他药物的副作用。然而，还需要进一步的研究。
Tourette Syndrome is a familial neurobehavioral disorder characterized by fluctuating involuntary motor and/or vocal ties. The most commonly used medications to treat Tourette's syndrome are haloperidol, pimozide, fluphenazine, and clonidine, all of which may have considerable side effects. We enrolled 450 patients with tics/Tourette's syndrome to be treated with baclofen/botolinum toxin type A for their symptoms. Global severity of tic symptoms was rated by the Yale Global Tic Severity Scale and a quantified videotaped micro-structured analysis of ties. We found that baclofen/botolinum toxin type A are very effective, safe, and reliable in the treatment of tics/Tourette's syndrome. It is worthwhile considering this treatment approach in patients with tics/Tourette's syndrome in order to reduce or avoid the side effects of other medications. Further studies, however, are required.