Consensus definitions for glomerular lesions by light and electron microscopy: recommendations from a working group of the Renal Pathology Society
Consensus definitions for glomerular lesions by light and electron microscopy: recommendations from a working group of the Renal Pathology Society
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DOI：
10.1016/j.kint.2020.08.006
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发表时间：
2020-11-01
影响因子：
19.6
通讯作者：
Jennette, J. Charles
中科院分区：
文献类型：
--
作者：
Haas, Mark;Seshan, Surya V.;Jennette, J. Charles
在过去的20年里，出现了多个肾小球疾病的评分系统，以及用于研究肾小球疾病的病理学家和肾病学家联盟，包括病理结果与临床特征和结果的相关性。然而，这些联盟的成员以及其他肾脏病理学家和肾病学家在调查工作和常规实践中面临的一个重要限制仍然是缺乏一致性和精确度，无法清楚地定义作为评分系统基础的形态损害。针对这一问题，肾脏病理学会组织了一个工作组，以确定通过光学显微镜和电子显微镜观察到的最常见的肾小球病变，回顾文献以获取每种病变最常用的已发表定义，并在一系列在线和面对面会议上确定每种病变的共识术语和定义。定义的损害或异常发现不是针对任何单个疾病或疾病子集的，而是可以应用于所有肾小球疾病，并在用于评估和报告这些疾病的不同评分系统的背景下应用。除了促进肾小球疾病的研究，标准化的术语和定义应该有助于协调世界各地对医用肾脏疾病的报告，并导致更准确的诊断和更好的患者护理。
Over the past 2 decades, scoring systems for multiple glomerular diseases have emerged, as have consortia of pathologists and nephrologists for the study of glomerular diseases, including correlation of pathologic findings with clinical features and outcomes. However, one important limitation faced by members of these consortia and other renal pathologists and nephrologists in both investigative work and routine practice remains a lack of uniformity and precision in clearly defining the morphologic lesions on which the scoring systems are based. In response to this issue, the Renal Pathology Society organized a working group to identify the most frequently identified glomerular lesions observed by light microscopy and electron microscopy, review the literature to capture the published definitions most often used for each, and determine consensus terms and definitions for each lesion in a series of online and in-person meetings. The defined lesions or abnormal findings are not specific for any individual disease or subset of diseases, but rather can be applied across the full spectrum of glomerular diseases and within the context of the different scoring systems used for evaluating and reporting these diseases. In addition to facilitating glomerular disease research, standardized terms and definitions should help harmonize reporting of medical kidney diseases worldwide and lead to more-precise diagnoses and improved patient care.