Dendritic cell inhibition: memoirs from immunosuppressive viruses.
Dendritic cell inhibition: memoirs from immunosuppressive viruses.
复制标题
树突状细胞抑制：免疫抑制病毒的回忆录。
DOI：
10.1086/505355
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Oldstone,MichaelBA
中科院分区：
文献类型：
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作者：
Trifilo,MatthewJ;Hahm,Bumsuk;Zuniga,ElinaI;Edelmann,KurtH;Oldstone,MichaelBA
Altered or reduced immune responses are associated with many life-threatening diseases. Numerous cancers, as well as bacterial and viral infections, can take advantage of weakened adaptive immune responses to promote uncontrolled cellular growth or pathogen replication. Although some forms of immunosuppression are associated with age or genetic defects, evidence is emerging that infections also dramatically reduce functioning of the immune system. For example, HIV-1 infection severely depletes CD4+ T cell numbers and the related activity, a result eventually causing the overall impairment of adaptive immune responses termed AIDS [1]. With 140 million persons infected worldwide, HIV-induced AIDS is responsible for 13 million deaths per year, primarily as a result of opportunistic secondary infections. Another dramatic example of virus-induced immunosuppression comes from human infection with measles virus, which, despite the availability of an effective vaccine, currently infects 130 million persons worldwide, leading to∼ 1 million deaths annually, usually as a consequence of secondary infections [2, 3]. These examples illustrate the importance of the adaptive immune response and indicate that suppression of this system severely reduces the host’s ability to ward off infection.
