Type IV secretion system of Anaplasma phagocytophilum and Ehrlichia chaffeensis.
Type IV secretion system of Anaplasma phagocytophilum and Ehrlichia chaffeensis.
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嗜吞噬细胞无形体和恰菲埃里希体的 IV 型分泌系统。
DOI：
10.1111/j.1749-6632.2009.04527.x
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发表时间：
2009
影响因子：
5.2
通讯作者：
Cheng,Zhihui
中科院分区：
文献类型：
--
作者：
Rikihisa,Yasuko;Lin,Mingqun;Niu,Hua;Cheng,Zhihui
细胞内细菌病原体查菲埃里希体和嗜吞噬细胞无形体已经进化为感染白细胞并劫持这些宿主防御细胞的生物化合物和过程。细菌IV型分泌（T4 S）系统以ATP依赖性方式跨膜转运大分子，并且越来越多地被认为是一种毒力因子递送机制，允许病原体调节真核细胞功能以获得自身利益。在E. chaffeensisandA.嗜吞噬细胞菌在与新的宿主细胞相互作用后，E. chaffeensisandA.编码T4 S装置的嗜吞噬细胞基因被上调。递送的大分子被称为T4 S底物或效应物，因为它们影响和改变基本的宿主细胞过程，导致疾病发展。最近，A.嗜吞噬细胞菌160-kDa AnkA蛋白将通过T4 S系统递送到宿主细胞质中。因此，动态信号转导事件可能由宿主细胞中的T4 S底物诱导，以成功建立细胞内感染。对埃里希体和无形体T4 S效应子同源宿主细胞分子的进一步研究无疑将促进我们对专性胞内病原体与其宿主之间复杂相互作用的理解。这些数据可用于治疗、诊断和控制埃立克体病和无形体病。
The intracellular bacterial pathogensEhrlichia chaffeensisandAnaplasma phagocytophilumhave evolved to infect leukocytes and hijack biological compounds and processes of these host defensive cells. Bacterial type IV secretion (T4S) system transports macromolecules across the membrane in an ATP‐dependent manner and is increasingly recognized as a virulence factor delivery mechanism that allows pathogens to modulate eukaryotic cell functions for their own benefit. Genes encoding T4S system homologous to those of a plant pathogenAgrobacterium tumefacienshave been identified inE. chaffeensisandA. phagocytophilum. Upon interaction with new host cells,E. chaffeensisandA. phagocytophilumgenes encoding the T4S apparatus are upregulated. The delivered macromolecules are referred to as T4S substrates, or effectors, because they affect and alter basic host cellular processes, resulting in disease development. Recently,A. phagocytophilum160‐kDa AnkA protein was to be delivered by T4S system into the host cytoplasm. Thus, dynamic signal transduction events are likely induced by T4S substrates in the host cells for successful establishment of intracellular infection. Further studies onEhrlichiaandAnaplasmaT4S effectors cognate host cell molecules will undoubtedly advance our understanding of the complex interplay between obligatory intracellular pathogens and their hosts. Such data can be applied toward treatment, diagnosis, and control of ehrlichiosis and anaplasmosis.