Heart rate depression during sleep apnea depends on hypoxic chemosensitivity. A study at high altitude.
Heart rate depression during sleep apnea depends on hypoxic chemosensitivity. A study at high altitude.
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睡眠呼吸暂停期间心率下降取决于缺氧化疗敏感性。
DOI：
10.1164/ajrccm/141.1.39
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Takayuki Kuriyama
中科院分区：
文献类型：
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作者：
Shigeru Masuyama;T. Shinozaki;S. Kohchiyama;S. Okita;Hiroshi Kimura;Yoshiyuki Honda;Takayuki Kuriyama
为了阐明呼吸暂停时周期性呼吸（PB）时心率（HR）减慢反应及其与低氧性呼吸反应（HVR）的关系，我们于1986年在中国昆仑山5,360米对7名日本登山者进行了睡眠研究。分析PB伴呼吸暂停期间的呼吸暂停持续时间（APD）、动脉血氧饱和度变化（Δ SaO 2）和心率变化百分比（Δ HR%）。这些数据与在海平面评估的低氧心率和呼吸反应进行了比较。呼吸暂停期的HR（APD，10.8 +/- 1.2 s; Δ SaO 2，10.2 +/- 1.8%）显著小于PB缓解期的HR（分别为56.0 +/- 5.1/min和74.6 +/- 6.2/min）。这种HR减慢或加速根据通气中的关闭和打开活动交替。Δ HR%的大小与Δ SaO 2的大小具有显著相关性（p <0.01）。低HVR登山者HR下降对去饱和的敏感性（Δ HR%/Δ SaO 2）小于高HVR登山者。我们的结论是，这些结果可以归因于这样一个事实，即外周化学感受器对心血管中心的主要作用是迷走神经紧张，这种作用是由迷走神经肺充气反射覆盖。
To clarify the heart rate (HR) slowing response during periodic breathing (PB) with apnea and its relationship to hypoxic ventilatory response (HVR), sleep studies were done in seven Japanese climbers at 5,360 m in the Kunlun mountains of China in 1986. Apnea duration (APD), arterial oxygen saturation changes (delta SaO2), and the percentage of heart rate changes (delta HR%) during PB with apnea were analyzed. The data were compared with hypoxic heart rate and ventilatory responses assessed at sea level. HR during the apneic period (APD, 10, 8 +/- 1.2 s; delta SaO2, 10.2 +/- 1.8%) was significantly smaller than that during the ventilatory period of PB (56.0 +/- 5.1/min and 74.6 +/- 6.2/min, respectively). This HR slowing or acceleration alternated in accordance with off and on activities in ventilation. The magnitude of delta HR% had a significant correlation with that of delta SaO2 (p less than 0.01). The sensitivity of HR depression to desaturation (delta HR%/delta SaO2) was smaller in low HVR climbers than in high HVR climbers. We concluded that these results can be ascribed to the fact that the primary effect of peripheral chemoreceptors on the cardiovascular center is vagotonia, and the effect is overridden by the vagal pulmonary inflation reflex.