Clinical Analysis of 1593 Patients with Infectious Endophthalmitis: A 12-Year Study at a Tertiary Referral Center in Western China.
Clinical Analysis of 1593 Patients with Infectious Endophthalmitis: A 12-Year Study at a Tertiary Referral Center in Western China.
复制标题
对1593例感染性内脑炎的患者进行的临床分析：在中国西部的三级转诊中心进行了为期12年的研究。
DOI：
10.4103/0366-6999.235866
复制
发表时间：
2018-07-20
影响因子：
6.1
通讯作者：
Xu ZP
中科院分区：
文献类型：
--
作者：
Yang XB;Liu YY;Huang ZX;Mao Y;Zhao L;Xu ZP
感染性眼内炎是一种严重的眼部炎症，可导致毁灭性的视力丧失。该研究的目的是确定中国西部地区感染性眼内炎的人口统计学和临床特征，以便更好地预防和治疗该疾病。对2005年至2016年中国西部某三级转诊中心住院感染性眼内炎患者的病历进行回顾性横断面研究。感染性眼内炎的常见病因是外伤（82.6%）、内源性（7.8%）、眼科手术（6.9%）和角膜溃疡穿孔（2.7%）。这4个病因组在年龄、性别、摘除率、视力结局等方面存在差异。前6年病例数占总收集病例数的38.7%，后6年占61.3%。这两个时期的病因模式不同。共有51.3%的患者接受了平坦部玻璃体切除术，13.9%的患者接受了内脏摘除术，其余34.8%的患者接受了其他治疗。 670例有培养结果的病例中，培养阳性266例（39.7%），革兰氏阳性菌177例（66.5%），革兰氏阴性菌64例（24.1%），真菌感染11例（4.1%），多种病原体感染14例（5.3%）。近十年来，我国西部地区感染性眼内炎的发病率呈上升趋势。我国西部地区感染性眼内炎的人口统计学和临床特征有其自身特点，与发达国家不同。其中，开放性眼球外伤是引起眼内炎的最常见原因，外伤性眼内炎患者以男性为主，且大部分伤害与工作有关，提示我们应加强针对工作场所的眼部安全法规的教育和应用。
Infectious endophthalmitis is a severe ocular inflammation which can cause devastating visual loss. The aim of the study was to identify the demographic and clinical features of infectious endophthalmitis in Western China for better prophylaxis and treatment of this disease. A retrospective, cross-sectional study was conducted based on the medical records of inpatients having infectious endophthalmitis in a tertiary referral center in Western China between 2005 and 2016. The common cause of infectious endophthalmitis was trauma (82.6%), endogenous (7.8%), ophthalmic surgery (6.9%), and corneal ulcer with perforation (2.7%). These four etiological groups differed in age, gender, enucleation rate, visual outcome, etc. The number of cases in the first 6 years accounted for 38.7% of the total collection, which in the second 6 years accounted for 61.3%. The etiology patterns were different between these two periods. Altogether 51.3% of patients received pars plana vitrectomy, 13.9% of patients underwent evisceration, and the remaining 34.8% received other treatments. Of the 670 cases that had culture results, 266 (39.7%) were culture positive and 177 (66.5%) were Gram-positive organisms, 64 (24.1%) were Gram-negative organisms, 11 (4.1%) had fungal infection, and 14 (5.3%) were infected by multiple pathogens. There was an upward trend of the occurrence of infectious endophthalmitis in Western China for the past decade. The demographic and clinical characteristics of infectious endophthalmitis in Western China had its own characteristics and differed from those of developed countries. Here, open globe trauma was the most common cause of endophthalmitis, most traumatic endophthalmitis patients were male, and most of the injuries were work related, implicate that we should strengthen the education and application of ocular safety regulation specifically targeting the workplace.