Mouse mammary tumor virus DNA methylation: tissue-specific variation.
Mouse mammary tumor virus DNA methylation: tissue-specific variation.
复制标题
小鼠乳腺肿瘤病毒 DNA 甲基化：组织特异性变异。
DOI：
10.1016/0042-6822(84)90248-4
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发表时间：
1984
期刊：
影响因子：
3.7
通讯作者：
Cohen,JC
中科院分区：
文献类型：
--
作者：
Breznik,T;Traina-Dorge,V;Gama-Sosa,M;Gehrke,CW;Ehrlich,M;Medina,D;Butel,JS;Cohen,JC
BALB/c小鼠内源性的小鼠乳腺肿瘤病毒特异性DNA序列以组织特异性的方式显示出不同程度的甲基化。在哺乳期乳腺和脾脏的DNA中，MMTV特异性序列在特定的HpaII和HhaI位点发生了低甲基化。在内源性病毒基因组的末端重复序列中发现了这些可变的甲基化位点。Mtv-9基因中aHpaII位点的特异性低甲基化与1.6kb转录本在哺乳期乳腺中的表达有关。
Mouse mammary tumor virus-specific DNA sequences endogenous to the BALB/c mouse are shown to exhibit variable levels of methylation in a tissue-specific manner. In DNA from both lactating mammary gland and spleen, MMTV-specific sequences were hypomethylated at specificHpaII andHhaI sites. These variably methylated sites were found in the terminal repetitive sequences of the endogenous viral genomes. The specific hypomethylation of aHpaII site inMtv-9 is associated with expression of a 1.6 kb transcript in the lactating mammary gland.