Pioneer factors - key regulators of chromatin and gene expression.
Pioneer factors - key regulators of chromatin and gene expression.
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先锋因素 - 染色质和基因表达的关键调节因子。
DOI：
10.1038/s41576-023-00648-z
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Bulyk ML
中科院分区：
文献类型：
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作者：
Bulyk ML
先锋因子是一类在发育过程中对基因调控起重要作用的转录因子。它们独特的能力，结合到压实的染色质，促进其重塑基因表达，使它们有别于其他调节蛋白，使它们在细胞分化，命运决定和重编程的重要球员。在这里，我们邀请了五位专家讨论我们目前对先锋因子及其功能的理解，以展示为什么探索这些蛋白质可以为基因调控和细胞身份提供独特的见解。
Pioneer factors are a group of transcription factors with important roles in gene regulation during development. Their unique ability to bind to compacted chromatin, promoting its remodelling for gene expression, sets them apart from other regulatory proteins and makes them essential players in cellular differentiation, fate determination and reprogramming. Here, we have tasked five experts with discussing our current understanding of pioneer factors and their functions to showcase why exploring these proteins offers unique insights into gene regulation and cellular identity.