Drosophila, genetic screens, and cardiac function.
Drosophila, genetic screens, and cardiac function.
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DOI：
10.1161/circresaha.111.244897
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发表时间：
2011-09-16
影响因子：
20.1
通讯作者：
Rockman HA
中科院分区：
文献类型：
--
作者：
Wolf MJ;Rockman HA
The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century but only over the past few decades has this tremendous resource been the focus of cardiovascular research. Fly genetics offers sophisticated transgenic systems, molecularly-defined genomic deficiencies, genome-wide transgenic RNAi lines, and numerous curated mutants to perform genetic screens. As a genetically-tractable model, the fly facilitates gene discovery and can complement mammalian models of disease. The circulatory system in the fly is comprised of well-defined sets of cardiomyocytes and methodological advances have permitted accurate characterization of cardiac morphology and function. Thus, fly genetics and genomics offers new approaches for gene discovery of adult cardiac phenotypes to identify evolutionarily conserved molecular signals that drive cardiovascular disease.
