Levels of cofactors for lipoprotein lipase and lecithin-cholesterol acyltransferase in plasma patients with severe thermal injury.
Levels of cofactors for lipoprotein lipase and lecithin-cholesterol acyltransferase in plasma patients with severe thermal injury.
复制标题
严重热损伤血浆中脂蛋白脂肪酶和卵磷脂胆固醇酰基转移酶的辅助因子水平。
DOI：
10.1097/00004630-198801000-00006
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Stenoien,C
中科院分区：
文献类型：
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作者：
Vega,GL;Alaupovic,P;Zhang,ZJ;Tenjarla,G;Baxter,CR;Stenoien,C
严重热损伤患者会出现短暂性高甘油三酯血症，部分患者血浆中外源性甘油三酯（TG）清除率较低。这表明脂肪分解受损。在当前的研究中，我们测量了清除内源性和/或外源性 TG 所需的载脂蛋白水平。对总烧伤表面积平均为 52% ± 6% (SE) 的 25 名热损伤患者（18 名男性和 7 名女性）进行了为期九周的随访。在“禁食”12小时后，即在肠胃外施用脂肪乳之前，测量血浆脂质和载脂蛋白C-II、C-III、E和A-I的水平。血浆胆固醇和载脂蛋白 C-II、C-III 和 A-I 水平较低。然而，血浆TG水平没有异常升高，而apo E水平在正常范围内。结果表明，热损伤患者的 TG 代谢所需的脱辅基蛋白水平降低。这种情况可能导致对外源性 TG 不耐受。
Transient hypertriglycericlemia occurs in patients with severe thermal injury, and some patients have a low clearance of exogenous triglyceride (TG) from plasma. This suggests an impaired lipolysis. In the current study, we measured the levels of apolipoproteins required for clearance of endogenous and/or exogenous TG. Twenty-five thermal injury patients (18 men and 7 women) having an average of 52% ± 6% (SE) total burn surface area were followed for a period of nine weeks. The levels of plasma lipids and apolipoproteins C-II, C-III, E, and A-I were measured after a 12-hour “fast,” ie, prior to the parenteral administration of fat emulsion. The levels of plasma cholesterol and apolipoproteins C-II, C-III, and A-I were low. Plasma TG levels, however, were not abnormally elevated, while apo E levels were within normal range. The results indicate that thermally injured patients have reduced levels of apoproteins necessary for TG metabolism. This condition may predispose to intolerance of exogenous TG.