Temporal evolution of cortical ensembles promoting remote memory retrieval
Temporal evolution of cortical ensembles promoting remote memory retrieval
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DOI：
10.1038/s41593-018-0318-7
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发表时间：
2019-03-01
影响因子：
25
通讯作者：
Luo, Liqun
中科院分区：
文献类型：
--
作者：
DeNardo, Laura A.;Liu, Cindy D.;Luo, Liqun
可怕事件的记忆可以持续一生。前额叶皮层的一个亚区--边缘前皮层在恐惧记忆的提取过程中起着关键作用。大多数研究都集中在最近记忆的获取、巩固和检索上，但对远程记忆的神经机制知之甚少。使用一种新的敲入小鼠的活动依赖性遗传标记（TRAP 2），我们证明，在PL皮质的神经元合奏是动态的。与学习或早期记忆提取过程中被捕获的PL神经元相比，在后期记忆提取过程中被捕获的PL神经元更有可能被重新激活，并对远程记忆提取做出更大的行为贡献。学习过程中的PL活动需要启动这种依赖于时间的重组PL合奏潜在的记忆检索。最后，虽然神经元TRAPed在早期和后期检索有类似的广泛的预测在整个大脑，PL神经元TRAPed后来有一个更强的功能招聘的皮质目标。
Memories of fearful events can last a lifetime. The prelimbic (PL) cortex, a subregion of prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have focused on acquisition, consolidation, and retrieval of recent memories, but much less is known about the neural mechanisms of remote memory. Using a new knock-in mouse for activity-dependent genetic labeling (TRAP2), we demonstrate that neuronal ensembles in the PL cortex are dynamic. PL neurons TRAPed during later memory retrievals are more likely to be reactivated and make larger behavioral contributions to remote memory retrieval compared to those TRAPed during learning or early memory retrieval. PL activity during learning is required to initiate this time-dependent reorganization in PL ensembles underlying memory retrieval. Finally, while neurons TRAPed during earlier and later retrievals have similar broad projections throughout the brain, PL neurons TRAPed later have a stronger functional recruitment of cortical targets.