Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.
Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.
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DOI：
10.1155/2010/475139
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发表时间：
2010
影响因子：
4.6
通讯作者：
Kovacs EJ
中科院分区：
文献类型：
--
作者：
Gomez CR;Karavitis J;Palmer JL;Faunce DE;Ramirez L;Nomellini V;Kovacs EJ
在这里，我们研究了从年轻和老年BALB/c野生型（WT）和IL-6敲除（IL-6 KO）小鼠中获得的脾巨噬细胞在体外产生细胞因子。与给予脂多糖（LPS）的幼年WT小鼠获得的巨噬细胞相比，老年WT小鼠获得的巨噬细胞产生的促炎细胞因子减少。相反，与来自年轻IL-6 KO小鼠的巨噬细胞相比，LPS刺激产生了更高水平的这些细胞因子。衰老或IL-6缺乏不影响F4/80+巨噬细胞的百分比，也不影响toll样受体4 （TLR4）和IL-6受体组分的表面表达。总之，我们的研究结果表明，IL-6通过改变促炎细胞因子来调节巨噬细胞的年龄相关缺陷，增加了IL-6介导的免疫细胞功能损伤随年龄增长的复杂性。
Here, we studied in vitro cytokine production by splenic macrophages obtained from young and aged BALB/c wild type (WT) and IL-6 knockout (IL-6 KO) mice. Relative to macrophages obtained from young WT mice given lipopolysaccharide (LPS), those from aged WT mice had decreased production of proinflammatory cytokines. In contrast, when compared to macrophages from young IL-6 KO mice, LPS stimulation yielded higher levels of these cytokines by cells from aged IL-6 KO mice. Aging or IL-6 deficiency did not affected the percentage of F4/80+ macrophages, or the surface expression of Toll-like receptor 4 (TLR4) and components of the IL-6 receptor. Overall, our results indicate that IL-6 plays a role in regulating the age-related defects in macrophages through alteration of proinflammatory cytokines, adding to the complexity of IL-6-mediated impairment of immune cell function with increasing age.
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影响因子：
5.3
作者：
Boehmer, ED;Meehan, MJ;Kovacs, EJ
通讯作者：
Kovacs, EJ
影响因子：
3.1
作者：
Arthur, WT;Vernon, RB;Reed, MJ
通讯作者：
Reed, MJ
影响因子：
3.9
作者：
De Cabo, R;Cabello, R;Navas, P
通讯作者：
Navas, P
影响因子：
5.5
作者：
Chelvarajan, R. Lakshman;Liu, Yushu;Bondada, Subbarao
通讯作者：
Bondada, Subbarao
影响因子：
5.5
作者：
Chelvarajan, RL;Collins, SM;Bondada, S
通讯作者：
Bondada, S