Variation of Aujeszky's disease viruses in wild swine in USA
Variation of Aujeszky's disease viruses in wild swine in USA
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DOI：
10.1016/j.vetmic.2010.02.013
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发表时间：
2010-06-16
影响因子：
3.3
通讯作者：
Lichtensteiger, Carol A.
中科院分区：
文献类型：
--
作者：
Hahn, Edwin C.;Fadl-Alla, Bahaa;Lichtensteiger, Carol A.
在美利坚合众国，Aujeszky病（伪狂犬病）已从所有家猪中根除。随着疫苗使用的减少，一些感染重新出现。由于野生猪的感染水库已经遍布美国南部三分之二的地区和夏威夷，也发生了零星的疫情。为了了解伪狂犬病病毒（PRV）的起源，对PRV的可变基因进行序列分析以区分毒株。在全国流行的猪伪狂犬病中，大多数来自野生猪的伪狂犬病病毒可以与家猪中流行的病毒区分开来。然而，来自中南部各州的几个野生猪PRV分离株与来自家猪的毒株在序列上密切相关或相同。用PCR方法对野猪口腔中病毒的存在进行了广泛的研究，发现病毒DNA广泛分布于扁桃体、唾液腺、味蕾甚至獠牙附近的粘膜中。显然，野生猪中的病毒具有多种传播机制，以确保持续感染，并且在家猪中重新出现的威胁仍在继续。(C)出版社：Elsevier B.V.
In the United States of America, Aujeszky's disease (pseudorabies) has been eradicated from all domestic swine. Some re-emergence of infection occurred as vaccine use diminished. Sporadic outbreaks have also occurred because of the reservoir of infection in feral swine that have spread across the southern two-thirds of the country and Hawaii. In order to be able to understand the origins of re-emerging virus, sequence analysis of variable genes in pseudorabies virus (PRV) has been used to differentiate strains. Most PRV from feral swine can be distinguished from virus circulating in domestic pigs during the national epizootic. However, several feral swine isolates of PRV from south central states are closely related or identical in sequence to strains from domestic pigs. Extensive study by PCR for the presence of virus in the oral cavity of feral pigs disclosed that the viral DNA is distributed widely in tonsils salivary glands, taste buds and even mucosa in the vicinity of tusks. Clearly the virus in feral swine has multiple mechanisms of transmission to insure persistent infection and the threat of re-emergence in domestic swine continues. (C) 2010 Published by Elsevier B.V.