CALCIUM AND PHOSPHATE-METABOLISM IN ACROMEGALY
CALCIUM AND PHOSPHATE-METABOLISM IN ACROMEGALY
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DOI：
10.1530/acta.0.0940459
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
HAUGEN, HN
中科院分区：
文献类型：
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作者：
HALSE, J;HAUGEN, HN
一项针对 28 名连续入院的活动性肢端肥大症患者的研究揭示了以下有关 Ca 和 P 代谢的结果。与对照组相比，校正总蛋白的血清 Ca 水平升高，尿 Ca 升高，但肾小管对 Ca 的重吸收正常。尿cAMP与Ca排泄呈负相关；肠道对钙的过度吸收是尿钙排泄增加的原因。肢端肥大症患者的血清 P 值增加，并且与 P/肾小球滤过率的最大肾小管重吸收密切相关，肾小球滤过率也增加。 5 例患者的免疫反应性甲状旁腺激素 (PTH) 升高，其中 3 例患有高钙血症。其余患者的 PTH 值分散在正常范围内。肢端肥大症患者尿 cAMP/肌酐比值增加，但当尿 cAMP 相对于 100 ml 肾小球滤液表达时，这种差异大部分被消除。显然，甲状旁腺功能亢进是肢端肥大症的一个特征。
A study of 28 consecutively admitted patients with active acromegaly revealed the following results with regards to Ca and P metabolism. When compared with controls, there was an increase in serum Ca levels corrected for total protein, urinary Ca was increased, but the tubular reabsorption of Ca was normal. There was a negative correlation between the urinary cAMP and Ca excretion; hyperabsorption of Ca from the gut is the cause of the increased urinary Ca excretion. Serum P values were increased in acromegalics and correlated well with maximum tubular reabsorption of P/glomerular filtration rate which was also increased. Immunoreactive parathyroid hormone (PTH) was increased in 5 patients, 3 of whom had hypercalcemia. In the remaining patients the PTH values were scattered within the normal range. The urinary cAMP/creatinine ratio was increased in acromegalics, but most of this difference was abolished when urinary cAMP was expressed relative to 100 ml of glomerulus filtrate. Apparently parathyroid hyperactivity is a feature of acromegaly.