Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: a retrospective study of 398 Japanese patients
Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: a retrospective study of 398 Japanese patients
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DOI：
10.1016/j.amjsurg.2010.09.030
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Sawada, Tokihiko
中科院分区：
文献类型：
--
作者：
Ishizuka, Mitsuru;Kubota, Keiichi;Sawada, Tokihiko
背景技术背景：格拉斯哥预后评分（GPS）在肝细胞癌（HCC）患者中的应用研究较少。方法：本研究比较了GPS和意大利肝癌计划（CLIP）评分在HCC手术患者中的预后价值。Kaplan-Meier分析显示GPS（P < .001）和CLIP评分（P < .001）与总生存率相关。GPS可将CLIP评分低（0或1）的患者分为3个独立组（P < .001）。单变量分析选择GPS（P = 0.006）和CLIP评分（P = 0.002）作为与总生存期相关的预测因素。使用这2个评分系统的多变量分析显示，GPS（P = 0.025）和CLIP评分（P = 0.010）与总survival.CONCLUSIONS：GPS不仅是一个重要的预测肝癌手术治疗后的总生存率以及CLIP评分，但也能够清楚地分为3个独立的组低CLIP评分的患者。(C)2012 Elsevier Inc. All rights reserved.
BACKGROUND: Few studies have investigated the Glasgow Prognostic Score (GPS) in patients with hepatocellular carcinoma (HCC).METHODS: This study compared the prognostic value of the GPS and Cancer of the Liver Italian Program (CLIP) score in patients undergoing surgery for HCC.RESULTS: A total of 398 patients were evaluated retrospectively. Kaplan-Meier analyses revealed that GPS (P < .001) and CLIP score (P < .001) were associated with overall survival. GPS could classify patients with low CLIP score (0 or 1) into 3 independent groups (P < .001). Univariate analyses selected GPS (P = .006) and CLIP score (P = .002) as the predictive factors associated with overall survival. Multivariate analysis using these 2 scoring systems disclosed that both GPS (P = .025) and CLIP score (P = .010) were associated with overall survival.CONCLUSIONS: GPS is not only an important predictor of overall survival after surgical treatment of HCC as well as CLIP score, but also is able to clearly divide patients with low CLIP score into 3 independent groups. (C) 2012 Elsevier Inc. All rights reserved.