GLYOXALASE SYSTEM IN CLINICAL DIABETES-MELLITUS AND CORRELATION WITH DIABETIC COMPLICATIONS
GLYOXALASE SYSTEM IN CLINICAL DIABETES-MELLITUS AND CORRELATION WITH DIABETIC COMPLICATIONS
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DOI：
10.1042/cs0870021
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发表时间：
1994-07-01
期刊：
影响因子：
6
通讯作者：
SONKSEN, PH
中科院分区：
文献类型：
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作者：
MCLELLAN, AC;THORNALLEY, PJ;SONKSEN, PH
1. 乙二醛酶系统对甲基乙二醛的代谢可能与糖尿病并发症的发生有关。乙二醛酶系统在胰岛素依赖型糖尿病患者（n=43）、非胰岛素依赖型糖尿病患者（n=107）和21名正常健康对照受试者的血液样本中进行了表征。2．相对于正常对照受试者，糖尿病患者的乙二醛酶代谢物、甲基乙二醛、S-D-乳酰谷胱甘肽和 D-乳酸的浓度增加：甲基乙二醛 [中位数，范围 (n) pmol/gl，胰岛素依赖型患者，470.7, 85.6-1044.3 (42)，P
1. The metabolism of methylglyoxal by the glyoxalase system may be linked to the development of diabetic complications. The glyoxalase system was characterized in blood samples from patients with insulin-dependent diabetes mellitus (n=43), patients with non-insulin-dependent diabetes mellitus (n=107) and 21 normal healthy control subjects.2. The concentrations of glyoxalase metabolites, methylglyoxal, S-D-lactoylglutathione and D-lactate, were increased in diabetic patients, relative to normal control subjects: methylglyoxal [median, range (n) pmol/gl, insulin-dependent patients, 470.7, 85.6- 1044.3 (42), P