Asthma is associated with Increased mortality in individuals with sickle cell anemia
Asthma is associated with Increased mortality in individuals with sickle cell anemia
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DOI：
10.3324/haematol.11213
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发表时间：
2007-08-01
期刊：
影响因子：
10.1
通讯作者：
DeBaun, Michael R.
中科院分区：
文献类型：
--
作者：
Boyd, Jessica H.;Macklin, Eric A.;DeBaun, Michael R.
对从出生到成年的镰状细胞性贫血 (SCA) 患者进行前瞻性队列分析，以确定哮喘是否是 SCA 死亡的危险因素。在调整已知的 SCA 死亡危险因素后，确定了参与者的全因死亡率。该研究纳入了 1,963 名受试者，随访时间为 18,495 患者年。在控制已确定的危险因素后，患有 SCA 和哮喘的个体的死亡风险高出两倍以上（风险比 2.36，95% CI 1.21 至 4.62，p=0.01）。总而言之，哮喘是 SCA 死亡的危险因素。
An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled from birth through adulthood, was conducted to determine if asthma is a risk factor for death in SCA. All-cause mortality was determined for participants after adjusting for known risk factors for death in SCA. The study included 1,963 individuals who were followed for 18,495 patient-years. After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA.