Antibacterial activity of 2-(2',4'-dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa.
Antibacterial activity of 2-(2',4'-dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa.
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DOI：
10.3390/md7030464
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发表时间：
2009-09-22
期刊：
影响因子：
5.4
通讯作者：
Mishra PD
中科院分区：
文献类型：
--
作者：
Shridhar DM;Mahajan GB;Kamat VP;Naik CG;Parab RR;Thakur NR;Mishra PD
2-(2‘，4’-二溴苯氧基)-4，6-二溴苯酚(2-(2‘，4’-dibromophenoxy)-4，6-dibromophenol，2-(2‘，4’-dibromophenoxy)-4，6-dibromophenol，2-(2‘，4’-dibromopenoxy)-4，6-dibromophenol，2-(2‘，4’-dibromophenoxy)-4，6-dibromophenol(2-(2‘，4’-dibromophenoxy)-4，6-dibromophenol)-2-(2‘，4’-dibromophenoxy)-4，6-dibromophenol(2‘，4’-dibromophenoxy)-4，6-dibromophenol(2-(2‘，4’-dibromophenoxy)-4，6-dibromophenol)-2-(2‘，4’-dibromophenoxy)-4，6-dibro对57株临床分离的革兰氏阳性菌和57株革兰氏阴性菌进行最低抑菌浓度(MIC)测定。对革兰氏阳性菌的最低抑菌浓度范围为0.117~2.5μg/m L，对革兰氏阴性菌的最低抑菌浓度范围为0.5~2μg/m L。观察到的体外抗菌活性优于市售的标准抗生素利奈唑胺。这些结果证实了2-(2‘，4’-二溴苯氧基)-4，6-二溴苯酚是一种潜在的抗MRSA和抗VRE药物开发的先导分子。
2-(2′,4′-Dibromophenoxy)-4,6-dibromophenol isolated from the marine sponge Dysidea granulosa (Bergquist) collected off the coast of Lakshadweep islands, Indian Ocean, exhibited potent and broad spectrum in-vitro antibacterial activity, especially against methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), vancomycin resistant Enterococci (VRE), vancomycin sensitive Enterococci (VSE) and Bacillus spp. Minimal inhibitory concentration (MIC) was evaluated against 57 clinical and standard strains of Gram positive and Gram negative bacteria. The observed MIC range was 0.117–2.5 μg/mL against all the Gram positive bacteria and 0.5–2 μg/mL against Gram negative bacteria. The in-vitro antibacterial activity observed was better than that of the standard antibiotic linezolid, a marketed anti-MRSA drug. The results establish 2-(2′,4′-dibromophenoxy)-4,6-dibromophenol, as a potential lead molecule for anti-MRSA and anti-VRE drug development.