Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy
Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy
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碳酸酯将喜树碱不饱和脂肪酸前药转化为用于癌症治疗的纳米药物
DOI：
10.1039/c8cc00639c
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发表时间：
2018-02-25
影响因子：
4.9
通讯作者：
Gou, Maling
中科院分区：
文献类型：
--
作者：
Li, Yang;Kang, Tianyi;Gou, Maling
我们报道了碳酸酯可以在水溶液中将疏水性喜树碱（CPT）-不饱和脂肪酸前药转化为纳米聚集体。当碳酸酯与二硫键结合时，一旦被还原刺激触发，活性CPT可以迅速释放，导致有效的体内抗肿瘤活性。
We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a potent in vivo antitumor activity.