Improved liver function following treatment with an extracorporeal liver assist device.
Improved liver function following treatment with an extracorporeal liver assist device.
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DOI：
10.1111/j.1525-1594.1993.tb00381.x
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发表时间：
2008-11
影响因子：
2.4
通讯作者：
N. Sussman;James H. Kelly
中科院分区：
文献类型：
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作者：
N. Sussman;James H. Kelly
一位68岁的女性，患有不明原因的暴发性肝衰竭，采用生物人工肝辅助装置进行治疗。在治疗前，她有许多临床和实验室特征表明没有希望的结果。治疗与她的精神状态的显著变化相关，在6天的连续治疗期间，她的临床表现逐渐改善。天然肝功能恢复的证据允许停止治疗，她继续改善了3 1/2天，然后死于脓毒性休克。我们认为，代谢活性肝辅助装置是治疗暴发性肝衰竭的关键阶段的一种逻辑和实用的方法。
A 68-year-old woman with fulminant hepatic failure of unknown etiology was treated with a bioartificial liver assist device. Prior to treatment, she had a number of clinical and laboratory features that suggested a hopeless outcome. Treatment was associated with a dramatic change in her mental status, and her clinical picture improved progressively during 6 days of continuous therapy. Evidence of recovery of native liver function allowed the discontinuation of treatment, and she continued to improve for a further 3 1/2 days before her demise from septic shock. We propose that a metabolically active liver assist device is a logical and practical method for treating the critical phase of fulminant hepatic failure.