Contribution of malaria and sickle cell disease to anaemia among children aged 6-59 months in Nigeria: a cross-sectional study using data from the 2018 Demographic and Health Survey.
Contribution of malaria and sickle cell disease to anaemia among children aged 6-59 months in Nigeria: a cross-sectional study using data from the 2018 Demographic and Health Survey.
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DOI：
10.1136/bmjopen-2022-063369
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发表时间：
2022-11-16
期刊：
影响因子：
2.9
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中科院分区：
文献类型：
--
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估计尼日利亚6-59个月儿童中由疟疾和镰状细胞病引起的贫血比例。尼日利亚2018年人口与健康调查（DHS）数据的横断面分析。尼日利亚：从随机选择的家庭中选出11,536名6-59个月大的儿童，符合参与条件，其中11,142名具有本分析所需的完整和有效的生物标志物数据。这些儿童中有10305名获得了产妇教育数据。血红蛋白浓度。我们发现70.6% （95% CI: 62.7%至78.5%）的严重贫血可归因于疟疾，而12.4% （95% CI: 11.1%至13.7%）的轻至重度贫血和29.6% （95% CI: 29.6%至31.8%）的中至重度贫血分别由SCD造成0.6% （95% CI: 0.4%至0.9%）、1.3% （95% CI: 1.0%至1.7%）和10.6% （95% CI: 6.7%至14.9%）的轻至重度、中至重度和重度贫血。镰状性状对贫血有保护作用，与血红蛋白（HbAA）正常的儿童相比，镰状性状与血红蛋白浓度较高有关。所采用的这种方法提供了一种新工具，可以利用广泛可得的人口与健康调查数据，在许多情况下估计疟疾对贫血的影响。在尼日利亚，由于疟疾和SCD导致的幼儿贫血比例在贫血程度越严重的情况下越高。预防疟疾和SCD以及及时治疗受影响的个体将减少严重贫血病例。
To estimate the fraction of anaemia attributable to malaria and sickle cell disease (SCD) among children aged 6–59 months in Nigeria. Cross-sectional analysis of data from Nigeria’s 2018 Demographic and Health Survey (DHS). Nigeria. 11 536 children aged 6–59 months from randomly selected households were eligible for participation, of whom 11 142 had complete and valid biomarker data required for this analysis. Maternal education data were available from 10 305 of these children. Haemoglobin concentration. We found that 70.6% (95% CI: 62.7% to 78.5%) of severe anaemia was attributable to malaria compared with 12.4% (95% CI: 11.1% to 13.7%) of mild-to-severe and 29.6% (95% CI: 29.6% to 31.8%) of moderate-to-severe anaemia and that SCD contributed 0.6% (95% CI: 0.4% to 0.9%), 1.3% (95% CI: 1.0% to 1.7%) and 10.6% (95% CI: 6.7% to 14.9%) mild-to-severe, moderate-to-severe and severe anaemia, respectively. Sickle trait was protective against anaemia and was associated with higher haemoglobin concentration compared with children with normal haemoglobin (HbAA) among malaria-positive but not malaria-negative children. This approach used offers a new tool to estimate the contribution of malaria to anaemia in many settings using widely available DHS data. The fraction of anaemia among young children in Nigeria attributable to malaria and SCD is higher at more severe levels of anaemia. Prevention of malaria and SCD and timely treatment of affected individuals would reduce cases of severe anaemia.
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