A new antitumor isoquinoline alkaloid from the marine nudibranch Jorunna funebris
A new antitumor isoquinoline alkaloid from the marine nudibranch Jorunna funebris
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DOI：
10.1016/s0040-4020(00)00629-3
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发表时间：
2000-09-08
期刊：
影响因子：
2.1
通讯作者：
Cimino, G
中科院分区：
文献类型：
--
作者：
Fontana, A;Cavaliere, P;Cimino, G
一种新的二聚异喹啉生物碱，jorumycin(3)，已从太平洋裸鳃Jorunna funebris的皮肤和粘液中分离出来。基于ESMS数据和广泛的二维核磁共振分析，该结构已得到充分阐明。3对多种人类癌细胞系的细胞毒性进行了评估，发现其效力略低于Et 743(2)。(C) 2000 Elsevier Science Ltd.。版权所有。
A new dimeric isoquinoline alkaloid, jorumycin (3), has been isolated from the skin and the mucus of the Pacific nudibranch Jorunna funebris. The structure has been fully elucidated on the grounds of ESMS data and of an extensive 2D NMR analysis. The cytotoxicity of 3 was evaluated against various human cancer cell lines and was found to be slightly less potent than Et 743 (2). (C) 2000 Elsevier Science Ltd. All rights reserved.