Impact of Androgen-Deprivation Therapy on Physical Function and Quality of Life in Men With Nonmetastatic Prostate Cancer
Impact of Androgen-Deprivation Therapy on Physical Function and Quality of Life in Men With Nonmetastatic Prostate Cancer
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DOI：
10.1200/jco.2010.29.8091
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发表时间：
2010-12-01
影响因子：
45.3
通讯作者：
Naglie, Gary
中科院分区：
文献类型：
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作者：
Alibhai, Shabbir M. H.;Breunis, Henriette;Naglie, Gary
目的：这项前瞻性纵向研究评估雄激素剥夺治疗（ADT）对客观和自我报告的身体function.Patients和方法男性非转移性前列腺癌（PC）开始连续ADT的效果被纳入这个匹配的队列研究。通过6分钟步行试验（6 MWT）、握力和计时起身行走（TUG）试验评估身体功能，分别代表耐力和上肢和下肢力量。生活质量（QOL）采用SF-36（医学结局研究简表36）问卷进行测量。在基线、3、6和12个月时对受试者进行评估。入组了两个对照组（PC无ADT;无PC），年龄、教育和基线功能匹配。混合效应回归模型进行拟合，调整基线covaries.Results我们招募了87例ADT患者，86 PC控制，和86名健康对照组，年龄（平均值，69.1岁;范围，50至87）和身体功能相似。ADT组的6 MWT距离保持稳定（P = .96），但两个对照组均有所改善（P < .05）。ADT组的握力下降（P = 0.04），PC对照组保持稳定（P = 0.31），健康对照组改善（P = 0.008）。TUG评分随时间和各组保持稳定（P < .10）。ADT组SF-36躯体功能总分下降（P < .001），而两个对照组均增加（P <0.01）。
Purpose This prospective longitudinal study evaluated the effect of androgen deprivation therapy (ADT) on objective and self-reported physical function.Patients and Methods Men with nonmetastatic prostate cancer (PC) starting continuous ADT were enrolled in this matched cohort study. Physical function was assessed with the 6-minute walk test (6MWT), grip strength, and the timed-up-and-go (TUG) test, representing endurance and upper and lower extremity strength, respectively. Quality of life (QOL) was measured with the Medical Outcomes Study Short-Form 36 (SF-36) questionnaire. Subjects were assessed at baseline, 3, 6, and 12 months. Two control groups (PC without ADT; no PC), matched on age, education, and baseline function were enrolled. Mixed effects regression models were fitted, adjusting for baseline covariates.Results We enrolled 87 patients on ADT, 86 PC controls, and 86 healthy controls; groups were similar in age (mean, 69.1 years; range, 50 to 87) and physical function. The 6MWT distance remained stable in the ADT group (P = .96) but improved in both control groups (P < .05). Grip strength declined in the ADT group (P = .04), remained stable in PC controls (P = .31), and improved in healthy controls (P = .008). TUG scores remained stable over time and across groups (P < .10). The SF-36 physical function summary score declined in the ADT group (P < .001), but increased in both control groups (P