Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients
Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients
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DOI：
10.1210/jc.2008-0241
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发表时间：
2008-09-01
影响因子：
5.8
通讯作者：
Vieth, Reinhold
中科院分区：
文献类型：
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作者：
Ish-Shalom, Sophia;Segal, Elena;Vieth, Reinhold
背景：维生素D的补充有不同的剂量方案，但它们之间缺乏比较数据。目的：我们的目标是确定相同累积剂量的维生素D3如果每天、每周或每月服用是否产生不同的效果。设计：年龄81+/-8岁(+/-SD，n=48)的接受手术修复髋部骨折的妇女随机接受维生素D3补充方案，每天1,500 IU，或每周10,500 IU，结果：最初，每日、每周和每月组的血清25(OH)D浓度分别为15.13+/-6.9、15.7+/-10.1和16.2+/-10.1 ng/ml。0.001)。在每月服药后的第一天，血清25(OH)D和1，25-二羟基维生素D均显著升高(P<；0.012)，而在每日或每周服药后的第二天，这两项指标均无显著变化。2个月后，每日、每周、每月补充维生素D的血清25(OH)D分别为33.2+/-8.5、29.2+/-8.9、37.1+/-10.3 ng/ml，差异无统计学意义。因此，剂量频率的选择可以根据哪种方法来优化个人对长期补充维生素D的依从性。
Background: Different dosing protocols have been used for vitamin D supplementation, but there has been a lack of comparative data among them.Objective: Our objective was to determine whether the same cumulative dose of vitamin D3 produces different effects if it is given daily, weekly, or monthly.Design: Women, age 81 +/- 8 yr (+/- SD, n = 48), who had undergone surgery to repair hip fracture were randomized to vitamin D3-supplementation protocols at 1,500 IU daily, or 10,500 IU once weekly, or 45,000 IU once every 28 d. The primary outcome measure was the serum 25-hydroxyvitamin D [25(OH) D] concentration attained.Results: Initially, serum 25(OH) D concentrations for daily, weekly, and monthly groups were, respectively, 15.13 +/- 6.9, 15.7 +/- 10.1, and 16.2 +/- 10.1 ng/ml. By d 7, these had increased significantly in all the groups (P < 0.001). On the first day after the monthly dose, both serum 25(OH) D and serum 1,25-dihydroxy vitamin D had increased significantly (P < 0.012 each), whereas these did not change significantly on the day after daily or weekly doses. After 2 months, serum 25(OH) D with daily, weekly, and monthly dosing were, respectively, 33.2 +/- 8.5, 29.2 +/- 8.9, and 37.1 +/- 10.3 ng/ml; there were no significant differences among these values.Conclusions: Supplementation with vitamin D can be achieved equally well with daily, weekly, or monthly dosing frequencies. Therefore, the choice of dose frequency can be based on whichever approach will optimize an individual's adherence with long-term vitamin D supplementation.