A lipophilic thioflavin-T derivative for positron emission tomography (PET) Imaging of amyloid in brain
A lipophilic thioflavin-T derivative for positron emission tomography (PET) Imaging of amyloid in brain
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DOI：
10.1016/s0960-894x(01)00734-x
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发表时间：
2002-02-11
影响因子：
2.7
通讯作者：
Klunk, WE
中科院分区：
文献类型：
--
作者：
Mathis, CA;Bacskai, BJ;Klunk, WE
合成了一种新的亲脂性硫黄素- t类似物（2-[4'-（甲氨基）苯基]苯并噻唑，6），对淀粉样蛋白具有高亲和力。在对照组小鼠中静脉注射[C-11]标记的6导致高脑摄取。系统注射未标记的6后，用多光子显微镜观察转基因活小鼠脑内淀粉样蛋白沉积。[C-11]6是一种很有前途的阿尔茨海默病淀粉样蛋白显像剂。(C) 2002 Elsevier Science Ltd.版权所有。
The synthesis of a new lipophilic thioflavin-T analogue (2-[4'-(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [C-11]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [C-11]6 is a promising amyloid imaging agent for Alzheimer's disease. (C) 2002 Elsevier Science Ltd. All rights reserved.