A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes
A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes
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DOI：
10.1038/onc.2009.243
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发表时间：
2009-10-01
期刊：
影响因子：
8
通讯作者：
Henshall, S. M.
中科院分区：
文献类型：
--
作者：
Boehm, M.;Locke, W. J.;Henshall, S. M.
加塔-2是加塔家族转录因子中的一员，参与雄激素受体（AR）信号传导，但其在前列腺癌中的作用尚不清楚。在这里，我们报告说，加塔-2表达在前列腺癌的一个相当大的比例和高表达的加塔-2与生化复发和远处转移进展，在一个验证集的203个癌症。体外数据显示，在用5 α-二羟基睾酮（DHT）对LNCaP前列腺癌细胞进行雄激素刺激24小时后，加塔-2被直接募集到AR的启动子区。雄激素缺乏条件下，异位加塔-2表达导致AR转录水平的诱导（P
GATA-2, a member of the GATA family of transcription factors, is involved in androgen receptor (AR) signaling, however, little is known regarding its role in prostate cancer. Here, we report that GATA-2 is expressed in a substantial proportion of prostate cancers and that high expression of GATA-2 is associated with biochemical recurrence and distant metastatic progression in a validation set of 203 cancers. In vitro data show that GATA-2 is directly recruited to the promoter region of the AR upon androgen stimulation of LNCaP prostate cancer cells with 5 alpha-dihydroxytestosterone (DHT) for 24 h. Ectopic GATA-2 expression causes the induction of AR transcript levels under androgen-depleted conditions (P