Speckle fluctuations and biomedical optics: implications and applications
Speckle fluctuations and biomedical optics: implications and applications
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DOI：
10.1117/12.60734
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发表时间：
1993-02
影响因子：
1.3
通讯作者：
J. Briers
中科院分区：
文献类型：
--
作者：
J. Briers
激光散斑限制了全息术所能达到的分辨率。由运动物体散射引起的时变散斑就更麻烦了。它可以破坏全息干涉测量中获得条纹所需的相关性，甚至，如果波动与所需的曝光时间相比很快，记录全息图所需的相干性。这些问题进行了讨论，特别是生物医学全息，并提出建议，以尽量减少其影响。文中还讨论了时变散斑的一些积极方面。波动服从与静止散斑图案的空间变化相同的统计。这些统计数据可用于测量散射粒子的运动，这是一种在生物医学科学中具有特殊价值的技术。潜在的应用包括监测血流、运动和细胞内活动。
Laser speckle limits the resolution that can be achieved in holography. Time-varying speckle, caused by scattering from moving objects, is even more troublesome. It can destroy the correlation needed to obtain fringes in holographic interferometry and even, ifthe fluctuations are rapid compared with the exposure time needed, the coherence needed to record a hologram. These problems are discussed, with particular reference to biomedical holography, and suggestions are made for minimizing their effect. Some positive aspects of time-varying speckle are also discussed. The fluctuations obey the same statistics as the spatial variations of a stationary speckle pattern. These statistics can be used to measure the movement of the scattering particles, a technique of particular value in biomedical science. Potential applications include monitoring blood flow, motility, and intracellular activity.