Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus
Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus
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DOI：
10.1111/j.2042-7158.2011.01407.x
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发表时间：
2012-03
影响因子：
3.3
通讯作者：
Beibei Zhang;Aili Cao;Jiyan Zhou;Zhibi Hu;Dazheng Wu
中科院分区：
文献类型：
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作者：
Beibei Zhang;Aili Cao;Jiyan Zhou;Zhibi Hu;Dazheng Wu
目的术后肠梗阻是造成术后并发症和延长住院时间的主要原因。黄连素是一种从药用植物小檗和黄连中分离得到的原小檗碱类生物碱，具有增强大鼠胃肠道胃窦和回肠平滑肌收缩力的作用。我们研究了麻风根碱是否可以抵消术后肠梗阻大鼠的胃肠道转运。
Objectives Postoperative ileus is major cause of postoperative complication and prolonged hospitalization. Jatrorrhizine, which is a protoberberine alkaloid isolated from the medicinal plants Berberis aristata and Coptis chinensis, has been found to increase contractility of gastric antral and ileum smooth muscles of rat gastrointestinal tract. We have investigated whether jatrorrhizine could offset gastrointestinal transit in rat with postoperative ileus.