Tissue level of advanced glycation end products is an independent determinant of high-sensitivity C-reactive protein levels in haemodialysis patients
Tissue level of advanced glycation end products is an independent determinant of high-sensitivity C-reactive protein levels in haemodialysis patients
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DOI：
10.1111/j.1440-1797.2010.01419.x
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发表时间：
2011-03-01
期刊：
影响因子：
2.5
通讯作者：
Okuda, Seiya
中科院分区：
文献类型：
--
作者：
Nagano, Makio;Fukami, Kei;Okuda, Seiya
目的：C反应蛋白（CRP）水平预测血液透析（HD）患者未来的心血管事件。晚期糖基化终末产物（AGE）在HD患者的心血管疾病（CVD）中发挥作用。然而，包括组织AGE水平在内的哪些变量与CRP独立相关仍然未知。因此，是否组织AGE和CRP水平与动脉粥样硬化在HD patients.Methods：54例HD患者进行了血液化学和组织AGE的测定。组织AGE水平通过测量皮肤自发荧光来评估。结果：单因素分析显示，年龄、白色细胞、血清白蛋白、碱性磷酸酶、抗酒石酸酸性磷酸酶5 b（TRAP5 b）和皮肤AGE水平与高敏C反应蛋白（hsCRP）显著相关。多元逐步回归分析显示血清白蛋白、TRAP5b和皮肤AGE水平是hsCRP的独立影响因素。结论：组织AGE水平是HD患者hsCRP水平的独立决定因素之一。组织AGE和hsCRP水平可能彼此相关，这可能有助于这些受试者动脉粥样硬化的进展。
Aim: C-reactive protein (CRP) level predicts future cardiovascular events in patients on haemodialysis (HD). Advanced glycation end products (AGE) play a role in cardiovascular disease (CVD) in HD patients. However, which variables including tissue AGE levels are independently associated with CRP remains unknown. Therefore, whether tissue AGE and CRP levels were correlated with atherosclerosis in HD patients was examined.Methods: Fifty-four HD patients underwent determinations of blood chemistries and tissue AGE. Tissue AGE levels were evaluated by measuring skin autofluorescence. Pulsatility index (PI) in the carotid artery was measured using a Doppler ultrasonography.Results: Univariate analyses showed that age, white blood cells, serum albumin (inversely), alkaline phosphatase (inversely), tartrate-resistant acid phosphatase 5b (TRAP5b) (inversely) and skin AGE levels were significantly correlated with high-sensitivity CRP (hsCRP). Multiple stepwise regression analysis revealed that serum albumin, TRAP5b and skin AGE levels were independent determinants of hsCRP. Further, PI was highest among HD patients with high skin AGE and high hsCRP levels.Conclusion: The present study suggests that tissue AGE level is one of the independent determinants of hsCRP in HD patients. Tissue AGE and hsCRP levels may be correlated with each other, which could in concert contribute to the progression of atherosclerosis in these subjects.