COMPARISON OF STREPTOKINASE AND HEPARIN IN TREATMENT OF ISOLATED ACUTE MASSIVE PULMONARY EMBOLISM
COMPARISON OF STREPTOKINASE AND HEPARIN IN TREATMENT OF ISOLATED ACUTE MASSIVE PULMONARY EMBOLISM
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DOI：
10.1136/bmj.2.5763.681
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发表时间：
1971-01-01
影响因子：
--
通讯作者：
HONEY, M
中科院分区：
文献类型：
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作者：
MILLER, GAH;SUTTON, GC;HONEY, M
23名患者经肺动脉造影证实存在大面积肺栓塞。所有患者均在栓塞发生后 2 至 48 小时内就诊，且均未患有心肺疾病。十五人接受链激酶治疗，八人接受肝素治疗。各组患者中影响预后和缓解率的因素相似，治疗前血流动力学或动脉造影结果无显着差异。治疗 72 小时后的血流动力学和动脉造影结果提供了客观的分辨率测量结果，链激酶治疗的患者的分辨率明显更高。两组均未出现死亡，但两名接受肝素治疗的患者由于临床恶化而不得不改变治疗。治疗的主要并发症是切割或手术部位出血，在链激酶治疗的患者中更常见。
Massive pulmonary embolism was confirmed by pulmonary arteriography in 23 patients. All were seen between 2 and 48 hours after the onset of embolism and none had pre-existing cardiorespiratory disease. Fifteen were treated with streptokinase and eight with heparin. Factors which might influence prognosis and rate of resolution were similar in the patients in each group, and there was no significant difference between the groups in terms of pretreatment haemodynamic or arteriographic findings. Haemodynamic and arteriographic findings after treatment for 72 hours provided an objective measurement of resolution, which was significantly greater in the streptokinase-treated patients. There was no mortality in either group, but treatment had to be changed in two heparin-treated patients because of clinical deterioration. The principal complication of treatment, seen more often in the streptokinase-treated patients, was bleeding from cut-down or operation sites.