Effects of exercise on knee joints with osteoarthritis: A pilot study of biologic markers
Effects of exercise on knee joints with osteoarthritis: A pilot study of biologic markers
复制标题
DOI：
10.1002/art.1790100108
复制
发表时间：
1997-02-01
影响因子：
4.7
通讯作者：
Vailas, AC
中科院分区：
文献类型：
--
作者：
Bautch, JC;Malone, DG;Vailas, AC
客观的。确定低强度负重运动对膝关节骨关节炎（OA）的影响，方法。测量滑液硫酸角质素（KS）和羟脯氨酸作为软骨退化的标志物。关节炎影响测量量表（AIMS）用于测量健康状况，干预前后使用视觉模拟量表进行疼痛评估。运动 (EX) 组 (n = 15) 接受每周三次、为期 12 周的低强度运动计划和每周教育计划，最低限度治疗 (Min RX) 组 (n = 15) 仅接受教育计划。 结果。 EX 组的疼痛水平有所下降，Min RX 组的 AIMS 有所改善，干预前后有 11 名受试者获得了滑液。 KS和羟脯氨酸的水平没有变化。结论。运动效果的进一步研究应包括临床和生物学参数，以检查运动作为膝关节骨关节炎治疗干预的结果。
Objective. To determine the effects of low intensity weight-bearing exercise on osteoarthritis (OA) of the knee,Methods. Synovial fluid keratan sulfate (KS) and hydroxyproline were measured as markers of cartilage degradation. The Arthritis Impact Measurement Scales (AIMS) were used to measure health status, and a visual analog scale for pain assessment was used before and after intervention. An exercise (EX) group (n = 15) received a thrice-weekly 12-week low intensity exercise program and a weekly educational program, and a minimal treatment (Min RX) group (n = 15) received only the education program.Results. Pain levels declined in the EX group, and the Min RX group showed improvement on the AIMS, Synovial fluid was obtained in 11 subjects before and after the intervention. Levels of KS and hydroxyproline did not change.Conclusion. Further study of exercise effects should include both clinical and biologic parameters to examine the outcome of exercise as a therapeutic intervention in OA of the knee.