Higher luteinizing hormone levels associated with antimullerian hormone in postmenarchal daughters of women with polycystic ovary syndrome
Higher luteinizing hormone levels associated with antimullerian hormone in postmenarchal daughters of women with polycystic ovary syndrome
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DOI：
10.1016/j.fertnstert.2018.10.011
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发表时间：
2019-02-01
影响因子：
6.7
通讯作者：
Sir-Petermann, Teresa
中科院分区：
文献类型：
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作者：
Crisosto, Nicolas;Ladron de Guevara, Amanda;Sir-Petermann, Teresa
目的：为了研究月经初潮后多囊卵巢综合征（PCOSd）妇女和对照妇女（Cd）的女儿之间的生殖和代谢差异。设计：病例对照研究。设置：临床内分泌科。患者：我们研究了月经初潮后1.5-6年的43例PCOSd和28例Cd。干预：人体测量、青春期发育、多毛症、口服葡萄糖耐量试验和GnRH类似物试验的测定。主要结果测量：Ferriman评分、性类固醇、促性腺激素、抗苗勒管激素（AMH）、卵巢体积、血糖和胰岛素水平。Ferriman评分、卵巢体积和AMH在PCOS d组较高。倾向评分分析显示，LH、LHFSH比率、T和游离雄激素指数、刺激后LH和LH-FSH比率以及2小时胰岛素存在显著差异，这可能仅归因于作为PCOS女儿的事实。广义线性模型显示，较高的LH水平与AMH和T水平呈正相关。结论：我们发现，高LH，雄激素和胰岛素水平存在于PCOS患者在月经后期，这可能是建立在成年期PCOS的发展基础。此外，LH水平与AMH水平相关，这支持AMH和LH的神经内分泌反馈存在于人类中，并且该特征可能在子宫内编程，如最近在小鼠中所示。((C)2018年美国生殖医学会（American Society for Reproductive Medicine）这个词在西班牙语里是最后的发音。
Objective: To study the reproductive and metabolic differences between daughters of women with polycystic ovary syndrome (PCOSd) and control women (Cd) after menarche.Design: Case-control study.Setting: Clinical endocrinology unit.Patient(s): We studied 43 PCOSd and 28 Cd 1.5-6 years after menarche.Intervention(s): Determination of anthropometry, pubertal development, hirsutism, oral glucose tolerance test, and GnRH analogue test.Main Outcome Measure(s): Ferriman score, sex steroids, gonadotropins, antimullerian hormone (AMH), ovarian volumes, and glucose and insulin levels.Result(s): The groups were similar in chronologic, gynecologic, and menarchal ages and anthropometric variables. Ferriman score, ovarian volumes, and AMH were higher in PCOSd. Propensity score analysis showed that there were significant differences in LH, LHFSH ratio, T and free androgen index, post-stimulated LH and LH-FSH ratio, and 2-hour insulin that could be attributed only to the fact of being a PCOS daughter. The generalized linear model showed that higher LH levels were positively associated with AMH and T levels.Conclusion(s): We found that higher LH, androgen, and insulin levels are present in PCOSd during the postmenarchal period, which may establish the basis for the development of PCOS during adulthood. Moreover, LH levels were associated with AMH levels, which supports that the neuroendocrine feedback proposed for AMH and LH is present in humans and that this feature is probably programed in utero, as recently shown in mice. ((C) 2018 by American Society for Reproductive Medicine.) El resumen esta disponible en Espanol al final del articulo.