Synthesis of acylnitroso intermediates and their synthetic applications
Synthesis of acylnitroso intermediates and their synthetic applications
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DOI：
10.2174/1570193053544445
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发表时间：
2005-04-01
影响因子：
2.3
通讯作者：
Nishiyama, H
中科院分区：
文献类型：
--
作者：
Iwasa, S;Fakhruddin, A;Nishiyama, H
酰基亚硝基中间体通常被称为超活性物种，总是在原位制备，并且可以容易地通过与二烯的杂Diels-桤木反应或通过烯反应与烯烃的杂Diels-Alder反应捕获，这为制备各种复杂且非常苛刻的有机分子开辟了一条宏伟的途径。酰基亚硝基的这两种反应已被证明是天然产物全合成中的关键合成工具。本文简要介绍了这些中间体的合成方法及其在天然产物全合成中的应用。
Acylnitroso intermediates are usually known as super reactive species, always prepared in situ and can be readily trapped via hetero-Diels-Alder reactions with dienes or with olefins via ene reactions, which open a magnificent access to produce a variety of complicated and very demanding organic molecules. Both of these reactions of acylnitroso species have been proved as the key synthetic tool in the total synthesis of natural products. The synthetic methods used to prepare these intermediates as well as their recent synthetic applications to the total synthesis of natural products are briefly described in this minireview.