Sequential MR imaging changes in nonketotic hyperglycinemia.
Sequential MR imaging changes in nonketotic hyperglycinemia.
复制标题
非酮症高甘氨酸血症的连续磁共振成像变化。
DOI：
--
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
B. Poll‐The
中科院分区：
文献类型：
--
作者：
J. Mourmans;C. Majoie;P. Barth;M. Durán;E. Akkerman;B. Poll‐The
对1例新生儿非酮症高甘氨酸血症（NKH）患者进行了弥散加权（DWI）和弥散张量成像（DTI）。3周时，此时正常有髓鞘的区域显示T2信号强度增加和扩散受限，与空泡性髓鞘病一致。在3个月时，这些地区增加了正常髓鞘形成的地形图，而分数各向异性是兼容的轴突保留。17个月时，扩散限制消失，可能是因为髓鞘空泡的合并。在先前有髓鞘的区域中观察到各向异性分数的减少，表明轴突丢失。我们的结论是DWI和DTI可以用来识别和表征NKH患者的白色束异常。
Serial diffusion-weighted (DWI) and diffusion tensor imaging (DTI) were performed in a patient with neonatal onset nonketotic hyperglycinemia (NKH). At 3 weeks areas that are normally myelinated at this time showed increased T2-signal intensity and restricted diffusion, consistent with vacuolating myelinopathy. At 3 months, these areas had increased in the topographic pattern of normal myelination, whereas fractional anisotropy was compatible with axonal sparing. At 17 months, diffusion restriction had disappeared, likely because of coalescence of myelin vacuoles. A decrease of fractional anisotropy was observed in the previously myelinated areas indicative of axonal loss. We conclude that DWI and DTI can be used to identify and characterize white matter tract abnormalities in patients with NKH.
非酮症高甘氨酸血症的大脑异常：MR 表现。
DOI：
--
发表时间：
1989
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Press,GA;Barshop,BA;Haas,RH;Nyhan,WL;Glass,RF;Hesselink,JR
通讯作者：
Hesselink,JR