Activated charcoal: in vivo and in vitro studies of effect on gas formation.
Activated charcoal: in vivo and in vitro studies of effect on gas formation.
复制标题
活性炭：对气体形成影响的体内和体外研究。
DOI：
10.1016/0016-5085(85)90129-5
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发表时间：
1985
期刊：
影响因子：
29.4
通讯作者：
Levitt,M
中科院分区：
文献类型：
--
作者：
Potter,T;Ellis,C;Levitt,M
据报道，摄入豆类后，活性炭可减少肠道气体产生，呼吸氢排泄减少和肠胃气排出减少就证明了这一点。在本研究中，我们通过体外和体内方法评估了活性炭减少肠道气体产生的能力。使用在添加或不添加碳水化合物的情况下孵育的人类粪便匀浆进行体外研究。在所有研究中，与未处理的对照相比，经木炭处理的匀浆中氢气和二氧化碳的产生和消耗发生率相似。通过双盲评估摄入烤豆粉后呼吸氢排泄和肠胃气排泄来研究活性炭对体内气体产生的影响。与安慰剂相比，摄入 16 粒活性炭胶囊（4 克）的受试者的呼吸氢浓度或排气次数没有观察到显着差异。我们得出的结论是，活性炭不会影响体外或体内的气体形成。
It has been reported that activated charcoal reduces intestinal gas production after ingestion of beans as evidenced by decreased breath hydrogen excretion and decreased passage of flatus. In the present study we assessed the ability of activated charcoal to reduce intestinal gas production by in vitro and in vivo methods. In vitro studies were performed using human fecal homogenates incubated with or without additional carbohydrate. In all studies hydrogen and carbon dioxide production and consumption occurred at similar rates in the charcoal-treated homogenate as compared with the untreated control. The influence of activated charcoal on gas production, in vivo, was studied by double-blind assessment of breath hydrogen excretion and flatus excretion after ingestion of a baked bean meal. No significant difference was observed in breath hydrogen concentration or number of passages of flatus in subjects who ingested 16 capsules of activated charcoal (4 g) as opposed to the placebo. We conclude that activated charcoal does not influence gas formation in vitro or in vivo.