Localization of α-synuclein to mitochondria within midbrain of mice
Localization of α-synuclein to mitochondria within midbrain of mice
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DOI：
10.1097/wnr.0b013e3282f03db4
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发表时间：
2007-10-08
期刊：
影响因子：
1.7
通讯作者：
Cai, Ding-Fang
中科院分区：
文献类型：
--
作者：
Li, Wen-Wei;Yang, Ru;Cai, Ding-Fang
α-突触核蛋白（α-syn）和线粒体之间的相互关系尚不清楚。由于缺乏信号肽及其主要定位于细胞质中，α-syn 通常被认为通过一些次级效应影响线粒体功能。与这一假设相反，我们在这里发现，一部分 α-syn 存在于正常多巴胺能神经元的线粒体膜中。在其他α-syn-阳性神经元中也发现了相同的特征。因此，与线粒体膜的结合是 a-syn 的生理性质，也可能导致该蛋白在帕金森病线粒体功能障碍中发挥病理作用。
The interrelationship between a-synuclein (alpha-syn) and mitochondria is not clearly understood. Owing to the lack of the signal peptide and its predominant localization in the cytosol, alpha-syn is generally considered to affect mitochondrial function through some secondary effects. Contrary to this assumption, here, we show that a portion of alpha-syn is present in the membrane of mitochondria in normal dopaminergic neurons. The same profile is also found in other alpha-syn-positive neurons. Thus, binding to the membrane of mitochondria is the physiological nature of a-syn and might also contribute to the pathological role of this protein in the mitochondrial dysfunction in Parkinson's disease.