Sleep and circadian informatics data harmonization: a workshop report from the Sleep Research Society and Sleep Research Network
Sleep and circadian informatics data harmonization: a workshop report from the Sleep Research Society and Sleep Research Network
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DOI：
10.1093/sleep/zsac002
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发表时间：
2022-02-08
期刊：
影响因子：
5.6
通讯作者：
Boudreau, Eilis
中科院分区：
文献类型：
--
作者：
Mazzotti, Diego R.;Haendel, Melissa A.;Boudreau, Eilis
越来越多的睡眠和昼夜节律数据的可用性和复杂性同样令人兴奋和具有挑战性。该领域的技术不断发展，产生比以往任何时候都更好的高分辨率生理和分子数据。然而，利用数百万患者进行大规模研究的前景受到数据共享和互操作性的次优方法的限制。因此，整合宝贵的临床和基础资源是有问题的，这阻碍了知识发现和将发现快速转化为临床护理。为了了解睡眠和昼夜节律领域的当前数据格局，睡眠研究学会（SRS）和睡眠研究网络（现在是SRS的一个工作组）在加拿大温哥华举行的2019年世界睡眠大会上组织了一次关于信息学和数据协调的研讨会。翻译信息学专家与睡眠研究专家齐聚一堂，讨论定义数据协调策略的机遇和挑战。本次研讨会的目标是推动讨论和促进支持多站点协作的数据集成和信息基础设施开发的创新方法。主要建议包括收集和存储可查找、可访问、可互操作和可重用的数据；确定支持睡眠和昼夜生物学研究的现有国际队列和资源；并定义最相关的睡眠数据元素和相关的元数据，这些元数据可以被早期的集成计划所支持。本报告介绍了一些基本概念，目的是促进睡眠/昼夜节律和信息学社区之间的接触，并呼吁在该领域实施和采用数据协调策略。
The increasing availability and complexity of sleep and circadian data are equally exciting and challenging. The field is in constant technological development, generating better high-resolution physiological and molecular data than ever before. Yet, the promise of large-scale studies leveraging millions of patients is limited by suboptimal approaches for data sharing and interoperability. As a result, integration of valuable clinical and basic resources is problematic, preventing knowledge discovery and rapid translation of findings into clinical care. To understand the current data landscape in the sleep and circadian domains, the Sleep Research Society (SRS) and the Sleep Research Network (now a task force of the SRS) organized a workshop on informatics and data harmonization, presented at the World Sleep Congress 2019, in Vancouver, Canada. Experts in translational informatics gathered with sleep research experts to discuss opportunities and challenges in defining strategies for data harmonization. The goal of this workshop was to fuel discussion and foster innovative approaches for data integration and development of informatics infrastructure supporting multi-site collaboration. Key recommendations included collecting and storing findable, accessible, interoperable, and reusable data; identifying existing international cohorts and resources supporting research in sleep and circadian biology; and defining the most relevant sleep data elements and associated metadata that could be supported by early integration initiatives. This report introduces foundational concepts with the goal of facilitating engagement between the sleep/circadian and informatics communities and is a call to action for the implementation and adoption of data harmonization strategies in this domain.