Role of galectin-3 in cardiac dysfunction induced by subarachnoid hemorrhage
Role of galectin-3 in cardiac dysfunction induced by subarachnoid hemorrhage
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DOI：
10.1016/j.expneurol.2023.114418
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发表时间：
2023-04-26
影响因子：
5.3
通讯作者：
Li，Feng-Xian
中科院分区：
文献类型：
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作者：
Huang，Xuan-Xuan;Zhang，Qian-Qian;Li，Feng-Xian
蛛网膜下腔出血(SAH)是一种严重的急性脑血管事件，不仅损害中枢神经系统，而且对包括心脏在内的其他各种器官也有负面影响。然而，潜在的机制仍不清楚。在这项研究中，我们发现患有SAH的小鼠表现出明显的心脏损伤，如QT和QTC间期延长，心脏纤维化，心脏射血分数减少。这一现象伴随着心脏中Galectin-3表达的增加，并可被Galectin-3抑制剂TD139逆转。有趣的是，我们还观察到SAH小鼠心脏组织内巨噬细胞Galectin-3的共表达增加。此外，当使用β-阻滞剂心得安抑制巨噬细胞的激活时，心功能得到改善，心脏组织中Galectin-3的表达减少。总之，我们的发现为Galectin-3在SAH相关心功能障碍中的作用提供了新的见解，并建议巨噬细胞-Galectin-3轴作为一种潜在的治疗策略。
Subarachnoid hemorrhage (SAH) is a severe acute cerebrovascular event that not only impairs the central nervous system but also negatively affects various other organs, including the heart. The underlying mechanisms, however, remain unclear. In this study, we discovered that mice with SAH exhibited significant cardiac injuries, such as extended QT and QTc intervals, cardiac fibrosis, and reduced cardiac ejection fractions. This phenomenon was accompanied by increased galectin-3 expression in the cardiac ventricle and can be reversed by galectin-3 inhibitor TD139. Interestingly, we also observed increased co-expression of galectin-3 in macrophage within the heart tissue of SAH mice. Additionally, when macrophage activation was suppressed using the beta-blocker propranolol, cardiac function improved, and galectin-3 expression in the cardiac tissue decreased. Collectively, our findings offer new insights into the role of galectin-3 in SAH-related cardiac dysfunction and suggest a macrophage-galectin-3 axis as a potential therapeutic strategy.