Newly designed hydrogel with both sensitive thermoresponse and biodegradability
Newly designed hydrogel with both sensitive thermoresponse and biodegradability
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DOI：
10.1002/pola.10595
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发表时间：
2003-03-15
影响因子：
--
通讯作者：
Okano, T
中科院分区：
文献类型：
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作者：
Yoshida, T;Aoyagi, T;Okano, T
以N-异丙基丙烯酰胺（IPAAm）与可生物降解的聚氨基酸交联的共聚物为基础，合成了温敏性水凝胶。该水凝胶由两种含聚氨基酸侧链和活性酯基的反应性IPAAm基共聚物制备。我们在PIPAAm共聚物中引入了由侧氨基引发的氨基酸N-羧基氰基脱羧聚合的接枝链。水凝胶很容易与可降解的聚（氨基酸）链交联，只需混合，共聚物水溶液。本研究中的胶凝方法将提供以下创新特征中的一些：（1）不需要去除未反应的单体等，（2）将药物更简单地装载到水凝胶中（仅在胶凝时混合），以及（3）更容易插入体内。在水凝胶的溶胀比测量的基础上，观察到依赖于温度变化的大体积变化。此外，酶的温度依赖性降解得到证实。结果表明，这些水凝胶可用于注射或植入基质的温度调节药物释放。(C)2003 Wiley Periodicals，Inc. J Polym Sci Part A：Polym Chem 41：779-787，2003.
The synthesis and characterization of thermoresponsive hydrogels on the basis of N-isopropylacrylamide (IPAAm) copolymers crosslinked with biodegradable poly(amino acids) are described. This hydrogel was prepared with two kinds of reactive IPAAm-based copolymers containing poly(amino acids) as the side-chain groups and activated ester groups. We introduced the graft chains by decarboxylation polymerization of amino acid N-carboxyanhydrides initiated from lateral amino groups in the PIPAAm copolymer. The hydrogels easily crosslinked with degradable poly(amino acid) chains by only mixing,the copolymer aqueous solutions. The gelling method in this study would provide some of the following innovative features: (1) no necessary removal of unreacted monomers and so forth, (2) simpler loading of drugs into the hydrogels (only mixing when gelling), and (3) easier insertion into the body. On the basis of the swelling ratio measurement of the hydrogel, large volume changes dependent on temperature changes were observed. Moreover, the enzymatic temperature-dependent degradation was confirmed. The results suggested that these hydrogels could be used for an injectable or implantable matrix of temperature-modulated drug release. (C) 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 779-787, 2003.