Conservation of the photoperiodic neuroendocrine axis among vertebrates: evidence from the teleost fish, Gasterosteus aculeatus.
Conservation of the photoperiodic neuroendocrine axis among vertebrates: evidence from the teleost fish, Gasterosteus aculeatus.
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DOI：
10.1016/j.ygcen.2012.03.010
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发表时间：
2012-08-01
影响因子：
2.7
通讯作者：
Cresko, William A.
中科院分区：
文献类型：
--
作者：
O'Brien, Conor S.;Bourdo, Ryan;Bradshaw, William E.;Holzapfel, Christina M.;Cresko, William A.
关键词：
光周期，或一天的长度，有一个可预测的年周期，使其成为许多生物季节性行为和发育时间的重要线索。光周期在温带和极地动物中被广泛用于调节性成熟的时间。光周期的正确感知和解释与生物体的整体适应性密切相关。在光周期哺乳动物和鸟类中，甲状腺激素途径启动性成熟，但这种途径在其他脊椎动物中的保守程度尚不清楚。我们使用的threespine棘鱼Gasterosteus aculeatus，作为一个代表性的硬骨鱼量化的光周期反应的关键基因在甲状腺激素途径在受控的实验室条件下。我们发现，激素的光周期反应在很大程度上是一致的多个群体之间，虽然差异表明生理适应各种气候。我们的结论是，甲状腺激素途径启动性成熟的光周期反应在G。aculeatus，我们的研究结果表明，更多的组成部分，这一途径是保守的哺乳动物，鸟类和硬骨鱼比以前已知的。然而，需要进行额外的内分泌学、细胞生物学和分子研究，以精确定义该途径的哪些方面在脊椎动物中是保守的。
Photoperiod, or length of day, has a predictable annual cycle, making it an important cue for the timing of seasonal behavior and development in many organisms. Photoperiod is widely used among temperate and polar animals to regulate the timing of sexual maturation. The proper sensing and interpretation of photoperiod can be tightly tied to an organism’s overall fitness. In photoperiodic mammals and birds the thyroid hormone pathway initiates sexual maturation, but the degree to which this pathway is conserved across other vertebrates is not well known. We use the threespine stickleback Gasterosteus aculeatus, as a representative teleost to quantify the photoperiodic response of key genes in the thyroid hormone pathway under controlled laboratory conditions. We find that the photoperiodic responses of the hormones are largely consistent amongst multiple populations, although differences suggest physiological adaptation to various climates. We conclude that the thyroid hormone pathway initiates sexual maturation in response to photoperiod in G. aculeatus, and our results show that more components of this pathway are conserved among mammals, birds, and teleost fish than was previously known. However, additional endocrinology, cell biology and molecular research will be required to define precisely which aspects of the pathway are conserved across vertebrates.
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影响因子：
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作者：
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通讯作者：
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