Alternative Hydrogen Source for Asymmetric Transfer Hydrogenation in the Reduction of Ketones
Alternative Hydrogen Source for Asymmetric Transfer Hydrogenation in the Reduction of Ketones
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DOI：
10.1002/cctc.201500886
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发表时间：
2015-12
期刊：
影响因子：
4.5
通讯作者：
Russell J. Wakeham-;J. Morris;Jonathan M. J. Williams
中科院分区：
文献类型：
--
作者：
Russell J. Wakeham-;J. Morris;Jonathan M. J. Williams
cis‐1,4‐Butenediol is shown to be a highly active hydrogen source for asymmetric transfer hydrogenation in the reduction of ketones. With the use of a ruthenium catalyst, cis‐1,4‐butenediol is isomerised and subsequently oxidised to a lactone as an irreversible step, which provides the driving force for the asymmetric reduction of ketones.
