Structure and Absolute Configuration of Fumiquinazoline L, an Alkaloid from a Gorgonian-Derived Scopulariopsis sp Fungus
Structure and Absolute Configuration of Fumiquinazoline L, an Alkaloid from a Gorgonian-Derived Scopulariopsis sp Fungus
复制标题
柳珊瑚来源的真菌生物碱文喹唑啉 L 的结构和绝对构型
DOI：
10.1021/np4002042
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发表时间：
2013-04-01
影响因子：
5.1
通讯作者：
Wang, Chang-Yun
中科院分区：
文献类型：
--
作者：
Shao, Chang-Lun;Xu, Ru-Fang;Wang, Chang-Yun
Fumiquinazoline L (1) 是一种生物碱，具有通过桥接半胺键形成的七环骨架，是从柳珊瑚衍生的 Scopulariopsis sp. 中分离出来的。菌。通过综合光谱数据和X射线衍射分析鉴定了新化合物的结构和绝对构型。在1的酸水解过程中，观察到了缬氨酸残基的异构化，并在不同条件下进行了研究。 Fumiquinazoline L (1) 没有表现出细胞毒性或抗菌活性。
Fumiquinazoline L (1), an alkaloid with a heptacyclic skeleton formed via a bridging hemiaminal linkage, was isolated from a gorgonian-derived Scopulariopsis sp. fungus. The structure and absolute configuration of the new compound were identified by comprehensive spectroscopic data and X-ray diffraction analysis. During acid hydrolysis of 1, the isomerization of the valine residue was observed and also studied in different conditions. Fumiquinazoline L (1) showed no cytotoxic or antibacterial activities.