Synthesis and in vitro anti-leukemic activity analogues of JS-K, an anti-cancer lead of structural compound
Synthesis and in vitro anti-leukemic activity analogues of JS-K, an anti-cancer lead of structural compound
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DOI：
10.1016/j.bmcl.2007.12.044
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发表时间：
2008-02-01
影响因子：
2.7
通讯作者：
Saavedra, Joseph E.
中科院分区：
文献类型：
--
作者：
Chakrapani, Harinath;Goodblatt, Michael M.;Saavedra, Joseph E.
制备了抗癌先导化合物JS-K的结构类似物，并测定了它们的体外抗白血病活性。从相应的二醇二氮烯鎓阴离子释放一氧化氮的速率似乎不影响前药形式的抗白血病活性。鉴定了两种具有强效抑制活性和潜在有利毒理学特征的化合物。(C)2007爱思唯尔有限公司保留所有权利。
Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified. (C) 2007 Elsevier Ltd. All rights reserved.