Future treatment strategies for neuropathic pain.
Future treatment strategies for neuropathic pain.
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DOI：
10.1007/978-3-540-79090-7_17
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发表时间：
2009
影响因子：
--
通讯作者：
F. Marchand;Nicholas G. Jones;S. McMahon
中科院分区：
文献类型：
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作者：
F. Marchand;Nicholas G. Jones;S. McMahon
患有慢性疼痛的人的患病率极高，疼痛影响着全世界数百万人。因此，持续性疼痛是一个主要的健康问题和未满足的临床需求。慢性疼痛患者发病率高的原因在很大程度上是由于缺乏有效的疼痛控制。疼痛控制不佳的一个重要原因无疑是我们对慢性疼痛的根本原因的理解不足，因此我们的镇痛治疗手段有限。然而，通过靶向导致临床相关疼痛的新过程来开发新类别的镇痛药物有相当大的希望。在这一章中，我们强调了一些分子物种，这是未来神经性疼痛治疗的潜在治疗靶点。特别是，电压门控离子通道，神经炎症，蛋白激酶和神经营养因子的作用进行了讨论有关的神经性疼痛的产生，以及如何通过靶向这些分子，它可以提供更好的疼痛控制比目前可用。
The prevalence of people suffering from chronic pain is extremely high and pain affects millions of people worldwide. As such, persistent pain represents a major health problem and an unmet clinical need. The reason for the high incidence of chronic pain patients is in a large part due to a paucity of effective pain control. An important reason for poor pain control is undoubtedly a deficit in our understanding of the underlying causes of chronic pain and as a consequence our arsenal of analgesic therapies is limited. However, there is considerable hope for the development of new classes of analgesic drugs by targeting novel processes contributing to clinically relevant pain. In this chapter we highlight a number of molecular species which are potential therapeutic targets for future neuropathic pain treatments. In particular, the roles of voltage-gated ion channels, neuroinflammation, protein kinases and neurotrophins are discussed in relation to the generation of neuropathic pain and how by targeting these molecules it may be possible to provide better pain control than is currently available.